胃癌患者血清炎性因子水平的检验分析

目的:探讨胃癌患者血清炎性因子的表达水平检测在其临床诊治中的意义。方法:选取92例胃癌患者为观察组，并选择同期105例发生胃良性病变的患者作为良性病变对照组，同期76例急性胃炎和胃溃疡合并作为急性炎症对照组，对三组患者的肿瘤坏死因子-α（TNF-α）、中期因子（MK）、白细胞介素（IL）-6、白细胞介素（IL）-8和C-反应蛋白（CRP）表达水平进行检测，比较上述血清炎性因子在三组中的表达情况。结果:胃癌患者TNF-α、MK、IL-6、IL-8、CRP等血清炎性因子水平分别为（15.7±2.1）ng·L-1、（616.5±254.6）pg·ml-1、（12.6±2.4）ng·L-1、（234.3±31.4）ng·L-1、（12.3±2.6）mg·L-1，与胃良性病变组和急性炎症对照组比较，均明显增高，差异有统计学意义（P<0.05）。胃良性病变组上述血清炎性因子水平和急性炎症对照组比较，差异无统计学意义（P>0.05）。TNF-α、MK、IL-6、IL-8、CRP等血清炎性因子在胃癌组III期-IV期和发生淋巴结转移患者的表达水平，分别与I期-II期和无淋巴结转移患者相比显著增高，差异有统计学意义（P<0.05）。结论:TNF-α、MK、IL-6、IL-8、CRP等血清炎性因子与胃癌的发生和进展具有一定的相关性，有进一步扩大研究的价值。

Serum inflammatory cytokine levels in patients with gastric cnacer

Objective:To investigate serum inflammatory factors in patients with gastric cancer expression levels.Methods:Selected 92 cases of gastric cancer patients as observation group，same period 105 healthy subjects and 76 patients with benign gastric lesions as a control group.For three groups patients were detected for tumor necrosis factor -α (TNF-α)，midkine (MK)，interleukin (IL）-6，interleukin (IL）-8 and C- reactive protein (CRP） expression levels.Results:The patients with gastric cancer，TNF-α，MK，IL-6，IL-8，CRP and other inflammatory cytokines serum levels were (15.7±2.1）ng·L-1，(616.5±254.6）pg·ml-1，(12.6±2.4）ng·L-1，(234.3±31.4）ng·L-1，(12.3±2.6）mg·L-1，compared with benign lesions of the stomach and the healthy group were significantly higher(P<0.05).For benign gastric lesions above serum markers levels of inflammatory factors and health groups，the difference was not statistically significant (P>0.05).TNF-α，MK，IL-6，IL-8，CRP and other inflammatory cytokines in the serum of gastric cancer phase III -IV group of lymph node metastasis was significantly higher compared to the expression levels of patients with stage I-II and without lymph node metastasis，the difference was statistically significant (P<0.05).Conclusion:TNF-α，MK，IL-6，IL-8，CRP and other inflammatory factors in serum were correlated with gastric cancer.