免疫营养对老年非小细胞肺癌放疗患者T淋巴细胞亚群的影响

目的:探讨免疫营养支持治疗对于非小细胞肺癌（non-small cell lung cancer,NSCLC）行放疗的老年患者T淋巴细胞亚群的影响。方法:分析2012年7月至2014年3月在我院接受治疗的老年NSCLC患者的临床资料。将患者根据治疗方案分为观察组（放疗+免疫营养组）和对照组（放疗组）。比较两组患者放疗前后的营养状况及T淋巴细胞亚群。结果:本研究共纳入患者40例，观察组和对照组患者各20例。放疗前两组患者的ALB、PA水平均无统计学差异（P＞0.05），而放疗15d后观察组患者的ALB、PA水平均显著高于对照组(P＜0.05)；两组患者在放疗前的T淋巴细胞亚群结果均无统计学差异（P均>0.05）；放疗15d后，观察组患者的LC、CD3+、CD4+、CD4+/CD8+水平均显著高于对照组(P＜0.01)，而CD8+比例显著低于对照组(P＜0.01)，差异均有统计学意义。结论:免疫营养支持能显著改善NSCLC患者的营养状况及T淋巴细胞亚群紊乱状况。

Effects of immune nutrition on T lymphocyte subsets of NSCLC elderly patients treated with radiotherapy

Objective:To discuss the effects of immune nutrition on T lymphocyte subsets of NSCLC elderly patients treated with radiotherapy.Methods:Clinical data of elderly patients with NSCLC received treatment was retrospectively analyzed.Patients were divided into two groups according to the therapeutic regimen,observe group (radiotherapy+immune nutrition group) and control group (radiotherapy group).The nutritional status and T lymphocyte subsets before and after radiotherapy of patients in two groups were compared.Results:A total of 40 patients were retrospectively analyzed,including 20 in observe group and 20 in control group.The levels of ALB,PA and T lymphocyte subsets before radiotherapy of patients in two groups had no statistical difference.The levels of ALB and PA at 15 days after radiotherapy of patients in observe group were obviously higher than those in control group.The level of LC,CD3+,CD4+ and CD4+/CD8+ of patients in observe group was significantly higher than that in control group.Conclusion:Immune nutrition could significantly improve the nutrition status and T lymphocyte subsets homeostasis of patients with NSCLC.