局部晚期胃癌FDP方案新辅助化疗的疗效观察

目的:评估进展期胃癌患者新辅助化疗后再手术的临床疗效。方法:选择局部晚期胃癌患者44例分为两组:常规手术组和新辅助化疗+手术组，各22例，入院后行CT检查，新辅助化疗+手术组患者进行2个周期的新辅助化疗，再行CT复查，对比后进行手术治疗。结果:常规手术组肿瘤切除率为81.8％(18／22)，获得根治性切除率为45.5％(10／22),剖腹探查率为18.2％(4／22)；新辅助化疗+手术组肿瘤切除率为90.9％(20／22),获得根治性切除率为72.7％(16／22)，剖腹探查率为9.1％(2／22)。两组均无手术死亡病例，并发症发生率差异无显著性。结论:进展期胃癌患者在新辅助化疗后，再进行手术治疗，可以提高手术根治率和切除率。

Effect of reoperation of locally advanced gastric cancer treated by FDP after preoperative chemotherapy

Objective:To explore the efficacy of neoajuvant chemotherapy interms of resectablity for the patients with advanced gastric cancer．Methods:All 44 patients with advanced gastric cancer were randomly divided into routine surgical operation group and neoajuvant chemotherapy+surgical operation group．The patients were examined by CT before surgery．The patients in neoajuvant chemotherapy+surgical operation group received two cycles of neoajuvant chemotherapy，and then were evaluated by CT.Results:In routine surgical operation group，the overall resectability rate was 81.8％(18／22)，and the curative resection rate was 45.5％(10／22)，18.2％(4／22) was laparotomy rate.In neoauvant chemotherapy+surgical operation group，the overall respectability rate was 90.9％(20／22)，and the curative resection rate was 72.7％(16／22)，only 9.1％(2／22) was laparotomy rate．No mortality was observed．There were no significant difference between two groups of toxicities.Conclusion:The overall resectability rate and the curative resection rate are increased in patients with advanced gastric cancer after neoajuvant chemotherapy．