全反式维甲酸联合亚砷酸治疗儿童急性早幼粒细胞白血病疗效分析

目的:评价全反式维甲酸（all-trans retinoic acid,ATRA）联合亚砷酸(ATO)治疗儿童急性早幼粒细胞性白血病(acute promyelocytic leukemia,APL) 的疗效。方法:2009年8月至2013年4月于我院儿科就诊的APL患儿18例，将亚砷酸注射液（0.1% ATO）按6mg/m2稀释于50g/L的葡萄糖溶液200-400ml中，静脉滴注持续3-5h，1次/d，ATRA 20-35mg/(m·d)，口服，3次/d。结果:18例患儿获得完全缓解（CR）率为94.4%；12例初治患儿均获得CR，6例复发患儿中5例获得CR。获得缓解时间（26.2±1.2）天，无明显不良反应发生。结论:ATRA联合亚砷酸治疗儿童APL疗效显著，有效缩短达到CR的时间，毒副作用基本可以耐受，本方案可以有效缩短治疗时间，降低患儿家庭经济负担，对患儿长期治疗具有重要作用，是一种经济有效的治疗方案。

Curative effect of all-trans retinoic acid in combination with arsenic trioxide for children acute promyelocytic leukemia

Objective:To evaluate curative effect of all-trans retinoic acid combined with arsenic trioxide (ATO) for children acute promyelocytic leukemia.Methods:2009 to 2013 in our hospital 18 APL cases were treated by the arsenic trioxide injection (ATO) 0.1% 6mg/m2 to 50g/L glucose solution with 200-400ml,intravenous drip for 3-5h,1/d,ATRA 20-35mg/(m·d),oral,3/d.Results:18 cases were complete remission (CR) (94.4%);12 cases were CR,6 cases were recurrent,5 cases CR.Remission time was (26.2+1.2) days,and no obvious adverse reaction occurred.Conclusion:ATRA combined with ATO for APL children has very good curative effect,this scheme can effectively shorten the treatment time,is an economic and effective treatment.