宫颈癌患者血清CYFRA21-1、TPS、CA125和CEA表达的临床分析

目的:探讨宫颈癌患者血清CYFRA21-1、TPS、CA125、CEA表达和临床的相关性。方法:随机选取28例宫颈癌患者和同时期的宫颈上皮内瘤样病变患者31例，健康对照人群35例。化学发光分析法检测血清CYFRA21-1、TPS、CA125和CEA水平，观察其和宫颈癌临床分型、分期的关系。结果:宫颈癌组CYFRA21-1、TPS、CA125、CEA检出水平最高，分别为:（5.15±36.35）ng/ml、（129.45±74.73）U/L、（58.35±17.47）U/ml、（15.86±9.35）ng/ml；宫颈上皮内瘤样病变检出水平其次，分别为:（0.96±0.45）ng/ml、（53.12±21.56）U/L、（36.24±14.23）U/ml、（3.28±1.74）ng/ml；健康人群最低，分别为:（0.61±0.32）ng/ml、（36.71±17.35）U/L、（12.69±4.51）U/ml、（1.26±0.86）ng/ml，以上两两比较差异均有显著性差异(P<0.05)。宫颈癌Ⅰ-Ⅱ期和宫颈癌Ⅲ-Ⅳ期在CYFRA21-1、TPS、CA125、CEA水平上比较差异也有统计学意义（P<0.05）。结论:血清CYFRA21-1、TPS、CA125、CEA在宫颈癌患者中的表达明显高于宫颈上皮内瘤样病变和健康受试者，为临床诊治研究提供了新的思路和方向。其在宫颈癌诊断中是否具有较好的特异性，需做进一步的临床研究。

Clinical analysis of serum CYFRA21 -1,TPS,CA125 and CEA expression in cervical cancer patients

Objective:To investigate serum CYFRA21-1,TPS,CA125,CEA expression in cervical cancer and clinical significance.Methods:Randomly selected 28 cases of cervical cancer and 31 cases with tumor-like cervical intraepithelial lesions in the same period,35 cases of healthy control to test serum CYFRA21-1,TPS,CA125 and CEA levels.Results:In cervical cancer CYFRA21-1,TPS,CA125,CEA were highest with(5.15±36.35)ng/ml,(129.45±74.73)U/L,(58.35±17.47)U/ml,(15.86±9.35)ng/ml,cervical intraepithelial neoplasia detection with(0.96±0.45)ng/ml,(53.12±21.56)U/L,(36.24±14.23)U/ml,(3.28±1.74)ng/ml,the lowest in healthy population with(0.61±0.32)ng/ml,(36.71±17.35)U/L,(12.69±4.51)U/ml,(1.26±0.86)ng/ml,P＜0.05.In cervical cancer and cervical cancer stage Ⅰ-Ⅱ,Ⅲ-Ⅳ stage differences of CYFRA21-1,TPS,CA125,CEA levels were also statistically significant (P＜0.05).Conclusion:Serum CYFRA21-1,TPS,CA125,CEA expression in cervical cancer patients was significantly higher than that of cervical intraepithelial neoplasia and healthy subjects.