结直肠癌患者血清MIC-1的表达及意义

目的评价结直肠癌患者血清中巨噬细胞抑制因子1（MIC-1）的表达水平及其临床意义。方法测定152例未经放化疗结直肠癌患者及120例健康对照组的血清MIC-1、癌胚抗原（CEA）及糖链抗原19—9（CA19—9）zk平。结果结直肠癌患者血清MIC-1水平较健康对照组显著升高（P〈0．01），MIC-1水平与Dukes分期、分化程度、浸润深度、淋巴转移、远处转移相关（P〈0．01），与年龄、组织类型无关。MIC-1表达与CEA呈正相关（r=0．514；P〈0．01），联合CEA及CA19-9检测可提高结直肠癌诊断的敏感性和准确率。结论血清MIC-1联合CEA及CA19-9对结直肠癌诊断和鉴别诊断有一定的临床应用价值。

Expression of significance macrophage inhibitory cytokine 1 in colorectal carcinoma

objective] To evaluate the expression of macrophage inhibitory cytokine 1(MIC-1) in colorectal carcinoma and its clinical significance.Methods] MIC-1,CEA and CA19-9 serum levels were determined in 152 patients with colorectal carcinoma without radiotherapy or chemotherapy and 120 normal subjects.Results] There was a significant increase in serum MIC-1 levels in colorectal carcinoma group compared with normal controls(P<0.01).Serum MIC-1 level was correlated with Dukes stage,the level was higher in patients with higher Dukes stage.serum MIC-1 level had correlation with differentiation,infiltration extent,lymph node metastasis,distant metastasis(P<0.01),and no correlation with MIC-1 levels and age,tissue category.Serum MIC-1 was positive correlated with CEA(P<0.01;r=0.514),and combinations of CEA and CA199 can increase sensitivity and accuracy of colorectal carcinoma detection.Conclusion] Serum MIC-1 measurement combined with CEA and CA19-9 can aid in diagnosis and differential diagnosis of colorectal carcinoma.