盐酸左西替利嗪治疗慢性特发性荨麻疹的临床研究

目的：研究盐酸左西替利嗪治疗慢性特发性荨麻疹的疗效和安全性。方法：采用随机、双盲、对照的临床研究方法，对44例慢性特发性荨麻疹患者进行随机分组，试验组予以盐酸左西替利嗪片口服，对照组采用盐酸西替利嗪片口服，每日1次。观察治疗第7、14和28天的临床疗效和不良反应：结果：服药后第7、14和28天试验组和对照组的有效率分别为77．28％和68．18％、86．37％和77．28％、90．91％和81．82％。试验组略高于对照组，但差异并无显著性。试验中没有发生严重不良反应。结论：盐酸左西替利嗪治疗慢性特发性荨麻疹安全有效。

A clinical trial of levocetirizine in the treatment of chronic idiopathic urticaria

Objective:To evaluate the efficiency and safety of the new kind of second generation antihistamines(levoceti-rizine)in the treatment of chronic idiopathic urticaria.Methods:A randomized,double-blinded,parallel comparative clinical trial was performed in44patients.They were divided into two groups,which were treated with5mg /d levocetirizine or10mg /d cetirizine respectively.Results:At day7,14and28,the rates of efficiency were77.28%,86.37%,90.91%respectively in levocetirizine group and68.18%,77.28%,81.82%respectively in cetirizine group.There were no statistic differences of clinical efficiency between the two groups(P>0.05).No obvious and severe side effects appeared during the whole trial.Conclusions:Levocetirizine is effective and safe in the treatment of chronic idiopathic urticaria.