Detecting early bone changes using in vivo micro-CT in ovariectomized, zoledronic acid-treated, and sham-operated rats |
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| Authors: | E. Perilli V. Le B. Ma P. Salmon K. Reynolds N. L. Fazzalari |
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| Affiliation: | (1) Bone and Joint Research Laboratory, Surgical Pathology, SA Pathology and Hanson Institute, Frome Road, Adelaide, 5000, Australia;(2) Discipline of Pathology, University of Adelaide, Adelaide, Australia;(3) Vision Lab, Department of Physics, University of Antwerp, Antwerp, Belgium;(4) Skyscan NV, Kontich, Belgium;(5) School of Computer Science, Engineering & Mathematics, Flinders University, Adelaide, Australia |
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| Abstract: | Summary This study monitored in vivo the effect on bone microarchitecture of initiating antiresorptive treatment with zoledronic acid in rats at 2 weeks following ovariectomy, an early phase at which major degenerative bone changes have been found to occur. The treatment still facilitated the full reversal of cancellous bone loss in rat tibia, highlighting the importance of the time point of initiation of antiresorptive treatment. |
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