| GC颗粒对实验大鼠血液流变学及凝血功能的影响 |
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| 引用本文： | 周静,梁晓雯,龙军,方泰惠.GC颗粒对实验大鼠血液流变学及凝血功能的影响[J].现代中药研究与实践,2011(3):38-40. |
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| 作者姓名： | 周静 梁晓雯 龙军 方泰惠 |
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| 作者单位： | 南京中医药大学江苏省中药药效与安全性评价重点实验室,江苏南京210029 |
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| 摘 要： | 目的 观察GC颗粒对实验大鼠血液流变学及凝血功能的影响.方法 采用番泻叶水浸液灌胃16 d复制大鼠脾虚模型,给药7 d,测定血液流变学指标;正常大鼠灌胃给药7 d,测定APTT,PT,TT及出凝血时间.结果 GC颗粒能降低脾虚大鼠全血低、中、高切变率血液粘度、血浆粘度以及血小板聚集率,明显缩短大鼠凝血系统活化部分凝血酶...
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| 关 键 词： | GC颗粒 血液流变学 凝血功能 |
The Impact of GC Granule on Rats Hemorheology and Coagulation |
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| ZHOU Jing,LIANG Xiao-wen,LONG Jun,FANG Tai-hui.The Impact of GC Granule on Rats Hemorheology and Coagulation[J].Research and Practice on Chinese Medicines,2011(3):38-40. |
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| Authors: | ZHOU Jing LIANG Xiao-wen LONG Jun FANG Tai-hui |
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| Institution: | ( Jangsu key laboratory for pharmacology and safety evaluation of Chinese medicine, Nanjing 210029, China) |
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| Abstract: | Objective Observe the impact of GC granule on rats hemorheology and coagulation. Methods Spleen-deficiency model was established by gavage rats with senna aqueous infusion for 16 days, and then check the indicator of hemorheology. Normal rats by gavage for 7 days to determine activated partial thromboplastin time （APTT）, prothrombin time （PT）, thrombin time （TT） and coagulating time. Results GC granule can reduce blood low, medium and high shear rate blood viscosity, plasma viscosity and platelet aggregation, significantly shorten APTT, PT, TT and coagulating time of blood coagulation system in rats. Conclusion GC granule treatment of dysfunctional uterine bleeding may be related to which improve the hemorheology, shorten APTT, PT, TT and coagulating time of blood coagulation system in rats. |
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| Keywords: | GC granule hemorheology coagulation |
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