血清瘦素、脂联素等指标与2型糖尿病湿热证相关性研究

目的：研究2型糖尿病患者血清瘦素、胰岛素抵抗指数、脂联素、超氧化物歧化酶、血糖、胰岛素、体重指数、腰围等指标与湿热证之间的关系,以探讨湿热证在2型糖尿病辨证施治中的重要性。方法：61例患者分为湿热证31例,非湿热证30例。测量两组患者的身高、体重、腰围,测定血清瘦素、脂联素、超氧化物歧化酶、胰岛素、血糖,计算胰岛素抵抗指数、体重指数,分析上述指标与湿热证之间的关系并分析瘦素、脂联素与其它指标的相关性。选取健康体检者23例作为对照组,测量其血清瘦素、脂联素、超氧化物歧化酶,分别与两组2型糖尿病患者作比较。结果：两组2型糖尿病患者血清瘦素均高于对照组,脂联素和超氧化物歧化酶均低于对照组,差异有统计学意义。2型糖尿病患者两组比较,湿热证组的瘦素、体重指数、空腹胰岛素、胰岛素抵抗指数均高于非湿热证组,而脂联素水平则低于非湿热证组。2型糖尿病患者的血清瘦素与胰岛素抵抗指数呈正相关,脂联素与胰岛素抵抗指数呈负相关。结论：研究发现,2型糖尿病患者存在高瘦素、低脂联素血症。湿热证在2型糖尿病中占据重要地位,2型糖尿病患者湿热证与体重指数、血清瘦素、脂联素、胰岛素、胰岛素抵抗指数之间有直接相应关系。

Study on the Relationship between the Level of Leptin,Adiponectin,etc and Damp-Heat Syndrome in Type 2 Diabetes

Objective： To study the relationship between the level of leptin,adiponectin,superoxide dismutase（SOD）,blood insulin,blood glucose,insulin resistance index,body mass index,waist circumference and Damp-Heat Syndrome in Type 2 diabetes,to discuss the significance of Damp-Heat Syndrome in treatment based on syndrome differentiation of Type 2 diabetes,in order to find the objective evidence of differentiation of symptoms and signs of traditional Chinese medicine of Type 2 diabetes and to guide clinic treatment better.Methods： All 61 cases of Type 2 diabetes were divided into Damp-Heat Syndrome group and non-Damp-Heat Syndrome group according to symptom,pulse tracings and tongue demonstration.There are 31 cases in the Damp-Heat Syndrome group and 30 cases in the non-Damp-Heat Syndrome group.Body height,body weight and waist circumference of the patients were measured.The level of leptin,adiponectin,superoxide dismutase（SOD）,blood insulin,blood glucose of the patients were checked.Calculate the body mass index and insulin resistance index.The differences of all the indexes in the two groups were compared.Analysis the dependability between leptin,adiponectin and other indexes.In addition,leptin,adiponectin and superoxide dismutase of 23 persons who were healthy were checked and compared with the two groups of Type 2 diabetes.Results： The level of leptin of the two groups of Type 2 diabetes is significantly higher than those of the healthy persons.The levels of adiponectin and superoxide dismutase of the two groups of Type 2 diabetes is significantly lower than that of the healthy persons.The levels of leptin,fasting plasma insulin,insulin resistance index and body mass index of the patients in the Damp-Heat S yndrome group are higher than in the non-Damp-Heat Syndrome group.The level of adiponectin of the patients in the Damp-Heat Syndrome group is lower than that in the non-Damp-Heat Syndrome group.There is positive correlation between the level of leptin and insulin resistance index and negative correlation between adiponectin and insulin resistance index.Conclusion： There is high level of leptin and low level of adiponectin in the patients of Type 2 diabetes.Damp-Heat Syndrome is important in the differentiation of symptoms and signs in Type 2 diabetes.There is close relationship between Damp-Heat Syndrome and the level of leptin,adiponectin,fasting plasma insulin,insulin resistance index and body mass index.The level of leptin,adiponectin,fasting plasma insulin,insulin resistance index and body mass index can be the objective evidence of differentiation of symptoms and signs of Damp-Heat Syndrome and the appraisement of curative of Damp-Heat Syndrome.