滋阴清热化痰法治疗慢性失眠临床研究

目的：评价滋阴清热化痰法治疗慢性失眠阴虚痰热证的，临床疗效。方法：将80例辨证为阴虚痰热证的慢性失眠患者随机平均分为治疗组和对照组。治疗组予滋阴清热化痰方刺，对照组口服艾司唑仑，疗程28d。治疗前后进行匹兹堡睡眠质量指数（PSQI）和中医疗效评定，并观察不良反应情况。结果：治疗组有效率77．5％，对照组为52．5％，两组比较，差异有统计学意义（P〈0．05）。治疗组治疗前后比较，PSQI总评分及睡眠质量、入睡时问、睡眠时间、睡眠效率、睡眠障碍、日间功能障碍6个亚项评分差异均有统计学意义（P〈0．05或P〈0．01）。对照组治疗前后比较，eSQZ总评分及入睡时间、睡眠时间、睡眠效率3个亚项评分差异有统计学意义（P〈0．05）。治疗后治疗组与对照组比较，PSQI总评分及睡眠质量亚项评分差异有统计学意义（P〈0．05）。结论：滋阴清热化痰法对慢性失眠属于阴虚痰热者疗效显著。

Clinical Observation on Chronic Insomnia Treated by Nourishing Yin,Clearing Heat and Eliminating Phlegm

Objective：To Observe the therapeutic effect of Nourishing yin, clearing heat and eliminating phlegm on chronic insomnia by comparison with western medicine. Methods ：80 Cases of insomnia patients with yin deficiency and phlegm-fire were randomized into treatment group and control group,40 in each. The treatment group was administered the Decoction based on the principle of nourishing yin, clearing heat and eliminating phlegm,while the control group was administered 1 mg of Estazolam each night before sleeping. The treatment courses was 4 weeks in all. TCM symptoms and Pittsburg＇ s sleep quality index before and after treatment were evaluated for comparison. Results：The total effective rate in the treatment group and the control group was respectively 77.5% and 52.5% with significant differences （P 〈 0.05）. At the end of the course, In the treatment group there were significant improvement in the total scores of PSQI and 6 sub-items, i. e. sleep quality, falling asleep time, sleep time, sleep efficiency, sleep disorder, daytime disfunction （P 〈 0.05 or P 〈 O. 01 ）. In the control group there were significant improvement in the total scores of PSQI and 3 sub-items, i. e. falling a- sleep time, sleep time, sleep efficiency （ P 〈 0.05 ）. Bettern the two groups after treatment there were significant differences in the total scores of PSQI and sleep quality （ P 〈 0.05 ）. Conclusion ： The effective of heat-cleating and phlegm-eliminating to treat patients with chronic insomnia for vin-asthenia is significant.