不同年龄组血液流变学结果的变化及分析

目的探讨不同年龄组血液流变学指标的改变,为预防心脑血管疾病提供实验依据。方法采用北京赛科希德 SA-6000自动血液流变测试仪分别测定门诊、住院患者830例(其中中青年组280例、中老年组290例、高龄老年组260 例)和健康对照组838名(其中中青年人300名、中老年人280名、高龄老年人258名)的血液流变学结果的变化;同时按男女及年龄分组,分别比较两组检测结果,并进行统计学分析。结果中青年组血液流变学指标趋于增高,存在着显著性差异(P<0．001)。中老年组血液流变学指标也随之增高,差异有显著性意义(P<0．001)。而高龄老年组与正常老年组相比,各项指标均低于对照组,并有显著性差异(P<0．001)。结论全血粘度指标的升高存在青年化趋势;中老年组血液粘度及血液凝固性的增高,可作为心脑血管疾病的早期预防和诊治的依据;75岁以上的高龄老年组全血粘度偏低与老人各种功能衰退及血管动脉硬化以及进行药物治疗相关。

The Changes and Analysis of Hemorheological Results in Different Age Groups

Objective To investigate the changes of hemorheological indices in different age groups in order to be used as experimental evidences for preventing cardiovascular and cerebrovascular diseases. Methods The changes of hemorheological results of 830 outpatients and inpatients (including 280 patients in young and middle age group, 290 patients in pre-elderly group and 260 patients in elderly group) and 838 healthy controls (including 300 young and middle people, 280 pre-elderly people and 258 elderly people) were detected by SA-6000 automatic hemorheological testing instrument (Saikexide, Beijing), respectively. At the same time, grouped patients and healthy controls by sex and age, and compared and statistically analyzed the results in two groups. Results Hemorheological indices in young and middle age group was to show an increased tendency, showing significant difference (P<0.001). With the increase, hemorheological indices in pre-elderly group also increased significantly(P<0.001).Compared with elderly healthy controls, all indices in elderly group was significant decreased(P<0.001). Conclusions The increase of indices of whole blood viscosity was trending young. The enhancement of blood viscosity and coagulation in pre-elderly group may be used as evidence for early prevention, diagnosis and treatment of cardiovascular and cerebrovascular diseases. Whole blood viscosity on the low side in elderly group was related to dysfunction, arteriosclerosis and drug treatment.