| 2型糖尿病肾病患者巨噬细胞移动抑制因子及尿微量白蛋白的表达及其意义 |
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| 引用本文： | 吴碧红,孔耀中,肖观清. 2型糖尿病肾病患者巨噬细胞移动抑制因子及尿微量白蛋白的表达及其意义[J]. 实用医学杂志, 2011, 27(13). DOI: 10.3969/j.issn.1006-5725.2011.13.058 |
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| 作者姓名： | 吴碧红 孔耀中 肖观清 |
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| 作者单位： | 广东省佛山市第一人民医院肾内科,528000 |
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| 摘 要： | 目的:通过检测2型糖尿病肾病患者尿微量白蛋白 (mA1b)及巨噬细胞移动抑制因子(MIF),了解MIF及mA1b在2型糖尿病肾病患者中的变化.方法:将138例患者按WHO诊断标准分型,分为2型糖尿病肾病合并冠心病患者及2型糖尿病肾病但无明确冠心病依据的患者,采用ELISA法和免疫比浊法观察比较两组2型糖尿病肾病患者MIF及mA1b含量.结果:2型糖尿病肾病合并冠心病组患者MIF水平(32.61 ± 5.1)μg/L及mA1b水平(63.00 ± 15.2)mg/L高于无明确冠心病的患者MIF(14.32 ± 3.20)μg/L及mA1b(21.00 ± 10.00)mg/L,差异有统计学意义(均P ＜ 0.05),两组患者MIF及mA1b水平又均显著高于对照组MIF(6.37 ± 1.2)μg/L及mA1b(13.75 ± 5.75)mg/L.结论:检测糖尿病肾病患者 MIF 及mA1b,可作为诊断糖尿病肾病患者早期肾损害的参考指标.
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| 关 键 词： | 糖尿病肾病 冠心病 尿微量白蛋白 巨噬细胞移动抑制因子 |
Expression and significance of macrophage migration inhibitory factor and urinary albumin in type 2 diabetic nephropathy patients |
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| WU Bi-hong,KONG Yao-zhong,XIAO Guan-qing. Expression and significance of macrophage migration inhibitory factor and urinary albumin in type 2 diabetic nephropathy patients[J]. The Journal of Practical Medicine, 2011, 27(13). DOI: 10.3969/j.issn.1006-5725.2011.13.058 |
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| Authors: | WU Bi-hong KONG Yao-zhong XIAO Guan-qing |
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| Abstract: | Objective To understand the changes of microalbuminuria(mA1b) and macrophage migration inhibitory factor(MIF) in type 2 diabetes nephropathy patients. Methods According to WHO classification criteria,138 patients diagnosed,were divided into type 2 diabetic nephropathy with and without coronary heart disease. Blood MIF and mA1b in these two groups were detected by ELISA and immune turbidimetry respectively. Results Comparing with the type 2 diabetic nephropathy without coronary heart disease,the MIF and mA1b... |
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| Keywords: | Diabetic nephropathies Coronary heart disease Microalbuminuria Macrophage migration inhibitory factor |
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