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| 性别对HNPCC家系中hMLH1和hMSH2种系突变携带者患癌风险的影响 | |
| 引用本文： | 张渊智,张志芳,盛剑秋,李世荣,张帆,任艳敏,杨姝,高慧芳,冯燕. 性别对HNPCC家系中hMLH1和hMSH2种系突变携带者患癌风险的影响[J]. 胃肠病学和肝病学杂志, 2011, 20(6): 508-512 |
| 作者姓名： | 张渊智 张志芳 盛剑秋 李世荣 张帆 任艳敏 杨姝 高慧芳 冯燕 |
| 作者单位： | 1. 昆明市第一人民医院消化科,云南,昆明,650011 2. 河南省职工医学院附属医院麻醉科 3. 北京军区总医院消化科 |
| 摘 要： | 目的探讨性别对HNPCC家系中hMLH1和hMSH2种系突变携带者患癌累积风险度的影响。方法对14个HNPCC家系的94例hMLH1或hMSH2种系突变携带者，采用Kaplan-Meier法、Cox风险比例模型和对数秩检验等方法估计种系突变携带者分别在30岁、40岁、50岁、60岁等时的患癌累积风险度及分析不同性别间的差异。结果hMLH1或hMSH2种系突变携带者发生各种HNPCC相关恶性肿瘤的累积风险度随年龄的增大明显增高，男性携带者发生HNPCC相关肿瘤、结直肠癌等的风险度明显高于女性（P〈0．01），但在60岁时两者基本趋于一致，均达90％以上；男性与女性携带者发生胃癌的累积风险度差异无显著性（P〉0．05）。hMLH1与hMSH2种系突变携带者患癌风险度的差异无统计学意义。结论性别与HNPCC家系中hMLH1或hMSH2种系突变携带者患癌（尤其是结直肠癌）风险度密切相关，但中国人种系突变携带者患癌年龄较西方人提前；hMLH1与hMSH2种系突变携带者发生HNPCC相关恶性肿瘤的累积风险度无明显差异。 |
| 关 键 词： | 错配修复基因 遗传性非息肉性结直肠肿瘤 累积风险度 种系突变 |
Difference of cumulative cancer risk between man and woman hMLH1 or hMSH2 germline mutation carriers in hereditary nonpolyposis colorectal cancer families |
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| ZHANG Yuanzhi,ZHANG Zhifang,SHENG Jianqiu,LI Shirong,ZHANG Fan,REN Yanmin,YANG Shu,GAO Huifang,FENG Yan. Difference of cumulative cancer risk between man and woman hMLH1 or hMSH2 germline mutation carriers in hereditary nonpolyposis colorectal cancer families[J]. Chinese Journal of Gastroenterology and Hepatology, 2011, 20(6): 508-512 | |
| Authors: | ZHANG Yuanzhi ZHANG Zhifang SHENG Jianqiu LI Shirong ZHANG Fan REN Yanmin YANG Shu GAO Huifang FENG Yan |
| Affiliation: | ZHANG Yuanzhi1,ZHANG Zhifang2,SHENG Jianqiu3,LI Shirong3,ZHANG Fan1,REN Yanmin1,YANG Shu1,GAO Huifang1,FENG Yan11.Department of Gastroenterology,the First People's Hospital of Kunming,Kunming 650011,2.Department of Anesthesiology,the Affiliated Hospital of Henan Worker's Medical College,3.Department of Gastroenterology,Beijing Army General Hospital,China |
| Abstract: | Objective To investigate the difference of cumulative cancer risk between man and woman hMLH1 or hMSH2 germline mutation carriers in hereditary nonpolyposis colorectal cancer(HNPCC) families.Methods To follow up 94 cases of hMLH1 or hMSH2 germline mutation carriers in 14 HNPCC families,cumulative risk of HNPCC related malignant cancers was estimated by Kaplan-Meier method and Cox proportional hazards model,and the difference between man and woman carriers was analyzed by log rank test.Results Cumulative ris... |
| Keywords: | Mismatch repair gene Hereditary nonpolyposis colorectal cancer Cumulative risk Germline mutaiton |
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