| CADM1表达下调与大肠腺癌发生发展的关系 |
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| 引用本文： | 陈科全,刘思德,白杨,张亚历,彭亮.CADM1表达下调与大肠腺癌发生发展的关系[J].胃肠病学和肝病学杂志,2011,20(6):498-501. |
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| 作者姓名： | 陈科全 刘思德 白杨 张亚历 彭亮 |
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| 作者单位： | 1. 广州医学院第一附属医院消化内科,广东,广州,510120
2. 南方医科大学南方医院消化内科 |
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| 摘 要： | 目的探讨CADM1表达下调与大肠腺癌发生发展的关系。方法RT—PCR检测正常大肠组织、大肠腺瘤和大肠腺癌的CADM1mRNA表达；免疫组化法检测正常大肠组织、大肠腺瘤和大肠腺癌的CADMI蛋白表达。结果大肠腺瘤中CADM1表达无缺失或明显减少（P〉0．05）；部分大肠腺癌组织中CADM1表达下调，且有淋巴结转移患者比无淋巴结转移者更常见（P〈0．05），Dukes’C期和Dukes’D期患者比Dukes’A期和Dukes’B期患者更常见（P〈0．05）。结论CADM1表达下调在大肠腺癌中常见，特别是在进展期大肠腺癌，因此，CADM1在大肠腺癌发病机制中可能发挥重要作用。
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| 关 键 词： | CADM1基因 大肠腺瘤 大肠腺癌 |
Relationship between downregulation of CADM1 and the development of colorectal adenocarcinoma |
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| CHEN Kequan,LIU Side,BAI Yang,ZHANG Yali,PENG Liang.Relationship between downregulation of CADM1 and the development of colorectal adenocarcinoma[J].Chinese Journal of Gastroenterology and Hepatology,2011,20(6):498-501. |
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| Authors: | CHEN Kequan LIU Side BAI Yang ZHANG Yali PENG Liang |
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| Institution: | CHEN Kequan1,LIU Side2,BAI Yang2,ZHANG Yali2,PENG Liang21.Department of Gastroenterology,the First Affiliated Hospital of Guangzhou Medical University,Guangzhou 510120,2.Department of Gastroenterology,Nanfang Hospital,Southern Medical University,China |
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| Abstract: | Objective To study the relationship between downregulation of CADM1 and the development of colorectal adenocarcinoma.Methods Expression of CADM1 mRNA in the normal large intestine,colorectal adenoma and colorectal adenocarcinoma were detected by RT-PCR.Expression of CADM1 protein in the normal large intestine,colorectal adenoma and colorectal adenocarcinoma were detected by immunohistochemistry.Results CADM1 missing or significant reducing was not found in colorectal adenoma.CADM1 significantly reduced in a... |
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| Keywords: | CADM1 gene Colorectal adenoma Colorectal adenocarcinoma |
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