灯盏花提取物对青光眼视神经保护作用的临床观察

目的 评价灯盏花提取物对眼压已控制的青光眼视神经保护作用.方法 采用随机、双盲与安慰剂对照临床试验方法.对2009年10月至2009年在解放军第五医院眼科就诊符合纳入标准的青光眼患者共34例(42只眼),分为治疗组和对照组,分别给予口服益脉康胶囊和安慰剂,每两月观察安全(血压、肝功、肾功)及疗效指标(视力、视野、HRT),疗程6月,评价疗效.结果 治疗组与对照组两组治疗前及治疗后2月平均光敏感度组间比较P＞0.05,差异无统计学意义,而治疗4、6月后两组组间比较的P＜0.05,差异有统计学意义;两组治疗后2月视网膜平均光敏感度改善率组间比较P＞0.05,差异无统计学意义,而治疗4月后两组组间比较P＜0.05,差异有统计学意义.治疗6月后两组组间比较的P＜0.01,差异显著有统计学意义.结论 益脉康胶囊能提高视网膜平均光敏感度,随治疗时间延长,其改善率明显提高,表明灯盏花提取物对眼压已控制的青光眼有一定的视神经保护作用.

Abstract：

Objective To evaluate the action for optic nerve protection of engeron extracts in treating glaucoma with control of intraocular pressure. Methods Thiny-four patients (42 eyes) with glaucoma who met the inclusion criteria, in randomized, double-blind and placebo-controlled clinical trial were divided into treatment group and control group were given oral Yi Mai Kang capsules and placebo, observed every two months to test security (blood pressure, liver function, renal function) and outcome measures (visual acuity, visual field, HRT), and were evaluated after 6 months. Results The mean sensitivity of treatment group and control group, the difference was not statistically significant both before treatment and 2 months after treatment, (P＞0.05), but the difference of the two groups,4, 6 months after treatment were statistically significant (P ＜0.05). The average rate of retinal light sensitivity of the 2 months, the difFerence between two groups was not statistically significant (P ＞0.05), but the difference of the two groups, 4 months at/er treatment was statistically significant (P ＜0.05). There was statistically sipiificant difference 6 months after treatment between the two groups (P ＜0.01). Conclusions Yi Mai Kang Capsule can improve retinal mean sensitivity, with longer treatment time, the improvement rate is significantly increased. It indicates that the extract of Erigeron has certain protective effect of optic nerve on glaucoma with control of intraocular pressure.

Clinical Study on the action for optic nerve protection of erigeron extracts in treating glaucoma with control of intraocular pressure

Objective To evaluate the action for optic nerve protection of engeron extracts in treating glaucoma with control of intraocular pressure. Methods Thiny-four patients (42 eyes) with glaucoma who met the inclusion criteria, in randomized, double-blind and placebo-controlled clinical trial were divided into treatment group and control group were given oral Yi Mai Kang capsules and placebo, observed every two months to test security (blood pressure, liver function, renal function) and outcome measures (visual acuity, visual field, HRT), and were evaluated after 6 months. Results The mean sensitivity of treatment group and control group, the difference was not statistically significant both before treatment and 2 months after treatment, (P＞0.05), but the difference of the two groups,4, 6 months after treatment were statistically significant (P ＜0.05). The average rate of retinal light sensitivity of the 2 months, the difFerence between two groups was not statistically significant (P ＞0.05), but the difference of the two groups, 4 months at/er treatment was statistically significant (P ＜0.05). There was statistically sipiificant difference 6 months after treatment between the two groups (P ＜0.01). Conclusions Yi Mai Kang Capsule can improve retinal mean sensitivity, with longer treatment time, the improvement rate is significantly increased. It indicates that the extract of Erigeron has certain protective effect of optic nerve on glaucoma with control of intraocular pressure.