内皮素D-二聚体在婴幼儿肺炎并发心力衰竭进展中的作用及意义

目的研究婴幼儿肺炎并发不同程度心力衰竭时内皮素(ET)、D-二聚体(D-dimer)等变化及其内在联系,探讨该阶段血管内皮功能、凝血、纤溶功能的变化。方法选择肺炎及肺炎并发不同程度心力衰竭患儿80例作为试验组,健康婴幼儿20例作为对照组,均抽血检测ET、D-dimer值。结果各组间ET、D-dimer差异有统计学意义;心衰程度越重,ET、D-dimer越高,其中以肺炎并发重度心衰组明显,ET与D-dimer间呈正相关(r=0.42,P<0.01)。结论婴幼儿肺炎并发心力衰竭时存在内皮细胞功能紊乱和凝血、纤溶系统的激活。

Role of serum endothelin, D - dimer in the infants with pneumonia and heart failure

Objective To study the changes of serum endothelin (ET) and D-dimer in the infants with pneumonia and heart failure (HF) and to explore the changes of blood coagulation,fibrinolysis,and endothelial cell function.Methods 80 infants with pneumonia and different degrees of HF and 20 controls were studied.Serum ET,D-dimer were measured.Results ET,D-dimer in two groups were different.The more severe the HF was, the more increased ET,D-dimer were.There were positive relationship between ET and D-dimer(r=0.42,P<0.01).Conclusions The dysfunction of endothelial cell, the activation of coagulation and fibrinolysis system appears in the infants with pneumonia and HF.