| Abstract: | In poisoning caused by injection ofClostridiumperfringens type A toxin or a mixture of toxin with the filtrate of a culture ofClostridium butyricum, changes in the microcirculation in the mucous membrane of the retrobuccal pouch of golden hamsters were found. The microcirculatory changes took place in two phases. In the first phase vasomotor disturbances were observed, as shown by periodic changes in diameter of the arterial microvessels, and by plasmatization and a decrease in the number of functioning capillaries. The diameter of the veins showed no significant change. The second phase was characterized by persistent disturbances of the microcirculation: slowing of the blood flow in the arterial and venous portions, the appearance of regions of stasis, a retrograde blood flow, and arterial dilatation. The persistent disturbances of the microcirculation following injection of a mixture ofCl. perfringens toxin and filtrate of a broth culture ofCl. butyricum appeared sooner than those in response to injection of the toxin alone.Department of Microbiology, N. I. Pirogov Odessa Medical Institute. Laboratory of Pathophysiology of Extremal States, Institute of General Pathology and Pathological Physiology, Academy of Medical Sciences of the USSR, Moscow. (Presented by Academician of the Academy of Medical Sciences of the USSR A. N. Chernukh.) Translated from Byulleten' Éksperimental'noi Biologii i Meditsiny, Vol. 84, No. 11, pp. 552–554, November, 1977. |
