慢性心力衰竭与几丁质酶-3样蛋白-1的相关性探讨

目的：检测慢性心力衰竭（CHF）患者血浆几丁质酶-3样蛋白-1（YKL40）的水平。方法：选择2009年1月至2010年12月在广州市番禺区何贤纪念医院就诊的CHF97例作为研究组。其中NYHAⅠ／Ⅱ级组69例、NYHAⅢ／Ⅳ级组28例：选择同期40例健康体检者作为对照组。检测患者血浆YKL—40、糖化血红蛋白（HBAIc）、N-末端脑利钠肽前体（NT—proBNP）及LVEF等指标。结果：除LVEF及NT—proBNP外，研究组和对照组患者的一般资料差异无统计学意义（P〉0．05）；研究组患者YKL珈水平为（108±7．5）ng／mL，高于对照组的（62±5．6）ng／mL（P〈0．05）；NYHAⅢ／Ⅳ级组YKL-40水平为（118±8．2）ng／mL，高于NYHAⅠ／Ⅱ级组的（89±6．3）．g／mL（P〈0．05）。结论：CHF患者血浆YKL铷水平明显升高，这可能与CHF患者存在炎症反应有关：随着心力衰竭的加重，YKL-40水平升高更为明显。

Correlation between chitinase-3-like-1 protein and chronic heart failure

Objective： To investigate the level of chitinase-3-like-1 protein （YKL-40） in patients with CHF. Methods： Recruitment ran from January 2009 to December 2010. A total of 97 patients with CHF, consisting of 69 cases with NYHA class I- II and 28 with NYHA class III-IV, as well as 40 age-matched individuals for health check-up were included from Hexian Memorial Hospital of Panyu District. The level of YKL-40, glycosylated hemoglobin （HBAlc）, N-terminal natriuretic peptide precursor （NT-pro BNP）, left ventricular ejection fraction （LVEF） were examined. Results： There was no significant difference in baseline indices between both groups （ P 〉 0.05 ） with exception of LVEF and NT-pro BNP. Patients with CHF were featured by higher level （ P 〈 0. 05 ） of YKL-40 [ （ 108.0 ± 7.5 ） ng/mL] when compared with healthy controls [ （62.0 ± 5.6 ） ng/mL ]. An elevated level of YKL-40 （ P 〈 0.05 ） was noted in NYHA class III-IV group [ （118.0± 8.2） ng/mL], but not in NYHA class I- II group [ （89.0±6.3） ng/mL]. Conclusion： The elevated level of YKL-40 in patients with CHF, which aggravates as the severity of CHF advances, could have stemmed from the inflammatory responses.