肝细胞癌化疗栓塞后经皮瘤内注射无水乙醇的疗效

目的比较肝动脉化疗栓塞术(THAE)后经皮瘤内注射无水乙醇(PEI)与单纯THAE治疗单个肝细胞癌的疗效。方法53例肝细胞癌随机分成A(26例)、B(27例)两组。A组单纯THAE治疗;B组THAE治疗后,在CT引导下行PEI治疗。结果THAE组肿瘤治疗的部分缓解率为26.7%,1、2、3年生存率分别为56.0%、30.0%、0.0%。THAE+PEI组肿瘤治疗的部分缓解率为55.5%(P<0.05),1、2、3年生存率分别为91.0%、57.0%、22.0%(P<0.05)。结论THAE+PEI较单纯THAE对单个肝细胞癌的治疗更安全有效。

Effect of chemoembolization combined with percutaneous intra-neoplasm ethanol injection in the treatment of HCC

Objective To compare the clinical effect of transcatheter hepato-arterial chemoembolization(THAE)plus percutaneous intra-neoplasm ethanol injection(PEI)with simple THAE in the treatment of large and encapsulated hepatocellular carcinoma (HCC).Methods Forty -six patients with large HCC were randomly divided into two groups:group A included26patients,who were treated with THAE alone;while group B included27patients,who were treated with THAE+PEI .Results In group A,the partial response rate was only26.7%,the survival rate at1,2and3years was56.0%,30.0%and0.0%,respectively.In group B,the partial response rate was55.5%(P<0.05),and the survival rate at1,2and3years was91.0%,57.0%and22.0%(P<0.05),respectively.Conclusion The combined therapy of THAE with PEI is more effective and safe than THAE alone for the treatment of large and encapsulated HCC.