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The role of molecular strategies in the evaluation of surgical margins in oropharyngeal squamous cell carcinoma |
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| Authors: | Anastasios N. Kanatas Andrew T. Harris Michael Messenger David Houghton Simon N. Rogers |
| Affiliation: | 1. Oral and Maxillofacial Department, Leeds Dental Institute, The Worsley Building, Clarendon Way, Leeds, LS2 9LU, UK 2. Oral Biology, University of Leeds, Level 6 Worsley Building, Clarendon Way, Leeds, LS2 9LU, UK 3. Tissue Engineering Research, Department of Oral Biology, Leeds Dental Institute, Leeds, LS2 9LU, UK 4. Oral and Facial Specialties Department, Pinderfields General Hospital, Aberford Road, Wakefield, WF1 4DG, UK 5. Regional Maxillofacial Unit, Faculty of Health, Edge Hill University, University Hospital Aintree, Aintree Trust, L9 7LN, Liverpool, UK |
| Abstract: | The recurrence of a tumour at the resection margins in head and neck squamous cell carcinoma (HNSCC) has profound implications on the morbidity and mortality of the patient. At present HNSCC does not undergo any form of molecular analysis to aid treatment strategy and prognosticate for those individuals at higher risk of recurrence. This article aims to review current research into molecular strategies for tumour evaluation, highlighting conflicting evidence and possible novel concepts for further exploration. |
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