The deregulation of miR-133b is associated with poor prognosis in bladder cancer |
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| Authors: | Zhenfeng Shi Aihemaiti Kadeer Mopei Wang Bin Wen Min Li Jinxing Huang Yang Gao Enwei Liu Donghong Liu Deyong Jia Chengyuan Liang |
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| Affiliation: | 1. Department of Urology, The People’s Hospital of Xinjiang Uyghur Autonomous Region, Urumqi 830002, Xinjiang, PR China;2. Department of Oncology, Peking University Third Hospital, 49 North Garden Rd., Haidian District, 100191, Beijing, PR China;3. Department of Urology, The People’s Hospital of Shache County, 844700, Xinjiang, PR China;4. Xinjiang Medical University, 393 Xinyi Road, Urumqi, 830011, Xinjiang, PR China;5. Department of Urology, University of Washington, 850 Republican Street, Seattle, WA, 98109, United States;6. Department of Pharmacy, Shaanxi University of Science & Technology, Xi''an, 710021, PR China |
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| Abstract: | BackgroundMicroRNAs (miRNAs) are single-stranded, endogenous, non-coding RNAs that are increased or decreased in almost all cancer types, and they paly crucial roles in the tumorigenesis as well as development.Materials and methods90 patients diagnosed with bladder cancer were enrolled in the present study. The bladder cancer tissues or adjacent normal tissues were obtained from the tumor area or adjacent normal zone. The expression level of miR-133b was examined by quantitative real-time polymerase chain reaction assay (qRT-PCR). Survival curves were displayed by the Kaplan-Meier method, and differences between two survival curves were calculated by the log-rank test.ResultsThe expression levels of miR-133b in bladder tissues were significantly decreased when compared with the matched adjacent normal bladder tissues (P? ConclusionsThe present study showed that miR-133b might be associated with bladder cancer progression, and its down-regulation might be a biomarker for poor prognosis of bladder cancer. |
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| Keywords: | microRNA-133b Expression level Bladder cancer Prognosis |
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