Spondin-2 is a novel diagnostic biomarker for laryngeal squamous cell carcinoma |
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| Authors: | Haosheng Ni Tingting Ni Jia Feng Tingting Bian Yifei Liu Jianguo Zhang |
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| Affiliation: | 1. Department of Otorhinolaryngology, Affiliated Hospital of Nantong University, No. 20 Xi Si Road, Nantong, 226001, China;2. Department of Oncology, Nantong Tumor Hospital, No. 30 Tong Yang North Road, Nantong 226001, China;3. Department of Pathology, Affiliated Hospital of Nantong University, No. 20 Xi Si Road, Nantong, 226001, China |
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| Abstract: | Spondin-2, belongs to the SOX (SRY-related HMG box) gene family, plays a vital role in the development of malignancy, however, the role of Spondin-2 in laryngeal squamous cell carcinoma (LSCC) remains unknown. The aim of this study is to investigate the prognostic significance of and probable mechanism of Spondin-2 in LSCC. qRT-PCR, western blotting assays and IHC analysis demonstrated that Spondin-2 was significantly increased in LSCC tissues compared with adjacent non-tumorous tissues. In addition, high levels of Spondin-2 was associated with clinical stage, lymph node metastasis and pathology grade of LSCC patients (P ＜0.05). Kaplan-Meier analysis showed that patients with high expression of Spondin-2 had a lower overall survival rate (P＜0.05) than that with low expression of Spondin-2. Moreover, spondin-2 silencing inhibited the proliferation of LSCC cells through inhibiting the activation of PI3K/AKT signaling. In conclusion, spondin-2 might be a novel therapeutic target and prognostic biomarker for LSCC patients. |
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| Keywords: | Spondin-2 LSCC Clinicopathological characteristics 5-year survival ratio Prognostic biomarker PI3K/AKT signaling pathway |
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