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Echocardiographic Assessment for the Detection of Cardiotoxicity Due to Vascular Endothelial Growth Factor Inhibitor Therapy in Metastatic Renal Cell and Colorectal Cancers
Authors:Lara F. Nhola  Sahar S. Abdelmoneim  Hector R. Villarraga  Manish Kohli  Axel Grothey  Kimberly-Ann Bordun  Matthew Cheung  Ryan Best  David Cheung  Runqing Huang  Sergio Barros-Gomes  Marshall Pitz  Pawan K. Singal  Davinder S. Jassal  Sharon L. Mulvagh
Affiliation:1. Department of Cardiovascular Medicine, Mayo Clinic, Rochester, Minnesota;2. Department of Oncology, Department of Internal Medicine, Mayo Clinic, Rochester, Minnesota;3. Institute of Cardiovascular Sciences, University of Manitoba, Winnipeg, Manitoba, Canada;4. Section of Hematology/Oncology, Department of Internal Medicine, University of Manitoba, Winnipeg, Manitoba, Canada;5. Section of Cardiology, Department of Internal Medicine, University of Manitoba, Winnipeg, Manitoba, Canada;6. Division of Cardiology, Department of Medicine, Dalhousie University, Halifax, Nova Scotia, Canada;7. Division of Cardiology, Orman Heart Center, Assiut University, Assiut, Egypt
Abstract:
Keywords:Cardio-oncology  Echocardiography  Two-dimensional speckle-tracking echocardiography  VEGF inhibitors  Cardiotoxicity  BVZ  Bevacizumab  CTRCD  Cancer therapeutics–related cardiac dysfunction  GLS  Global longitudinal strain  GLSR-E  Global longitudinal early diastolic strain rate  GLSR-S  Global longitudinal systolic strain rate  ICC  Intraclass correlation coefficient  LV  Left ventricular  LVEF  Left ventricular ejection fraction  mCRC  Metastatic colorectal cancer  mRCC  Metastatic renal cell carcinoma  PAZ  Pazopanib  SNT  Sunitinib  VEGF  Vascular endothelial growth factor  VEGF-i  Vascular endothelial growth factor inhibitor
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