3种方案治疗儿童原发性遗尿症的药物经济学分析

目的：探讨3种方案药物治疗儿童原发性夜间遗尿症的经济效果。方法：152例患儿随机分为3组,分别给予醋酸去氨加压素（A组）、醋酸去氨加压素合并奥昔布宁（B组）和酸酸去氨加压素合并中药温肾止遗汤（C组）3种不同方案治疗。运用药物经济学中最小成本分析法（CMA）进行评价。结果：3种方案在临床疗效、不良反应发生率等方面无显著差异（P〉0.05）;药物治疗费用以B方案最低;而A方案复发率最高,与B、C两方案比较有显著差异（P〈0.05）。结论：醋酸去氨加压素合并奥昔布宁治疗方案复发率较低,成本低,更具经济学优势,而醋酸去氨加压素合并中药温肾止遗汤方案虽成本较高,但复发率最低,远期疗效理想。

Pharmacoeconomic Analysis on 3 Therapeutic Regimens for Primary Nocturnal Enuresis in Children

OBJECTIVE： To evaluate the pharmacoeconomic efficacy of 3 therapeutic schemes for primary nocturnal enuresis （PNE） in children. METHODS： A total of 152 PNE case were randomly divided into 3 groups： Group A received Desmopressin,Group B Desmopressin combined Oxybutynin and group C Desmopressin combined Wenshenzhiyi Tang （kidney - warming enuresis - arresting Chinese medicinal decoction）. The 3 schemes were evaluated using cost - minimization analysis （CMA） in pharmacoeconomics. RESULTS： There were no significant differences （P〈0. 05） across the 3 schemes in clinical efficacy and adverse drug reactions. Scheme B had the lowest treatment cost,while scheme A showed the highest recurrence rate compared with the other two schemes （ P〈0. 05）. CONCLUSION： Treatment of primary nocturnal enuresis （PNE） in children with Desmopressin combined Oxybutynin is optimal for its lower cost the lower recurrence rate; however,Desmopressin （ Minirin） combined Chinese medicinal decoction （Wenshenzhiyi Tang） involved the lowest recurrence rate and ideal long -term efficacy despite its higher cost.