联合应用热淋清治疗慢性前列腺炎的疗效观察

目的：探讨联合应用热淋清颗粒等药物治疗慢性前列腺炎的临床疗效。方法：采用随机对照临床观察的研究方法将慢性前列腺炎137例（其中细菌性前列腺炎24例,非细菌性前列腺炎113例）分为单纯化学药对照组（52例）和热淋清颗粒治疗组（85例）。对照组应用敏感抗生素、α1受体阻滞剂及温水坐浴等物理治疗;治疗组在上述治疗基础上,同时服用热淋清颗粒4g,每日3次。采用美国国立卫生研究所（NIH）制定的前列腺炎症状评分标准（CPSI）和两杯判定试验（PPMT）法及细菌学检查结果进行分析及疗效评价。结果：137例平均随访8.3个月,治疗前后进行NIH-CPSI、PPMT及细菌学检查结果比较。治疗组痊愈14.1%（12/85）、显效55.3%（47/85）、有效20%（17/85）、无效10.6%（9/85）。治疗前后NIH-CPSI分别为27.7（28.5±4.2）及13.2（12.9±3.6）,治疗前后比较差异有统计学意义（P〈0.01）。对照组痊愈7.7%（4/52）、显效17.3%（9/52）、有效46.2%（24/52）、无效28.8%（15/52）。治疗前后NIH-CPSI分别为27.2（27.8±3.6）及17.3（17.54±2.7）,治疗前后比较差异无统计学意义（P〉0.05）。治疗前后PPMT总有效率（WBC转为正常）治疗组与对照组分别为68.2%和34.6%,两者比较差异有统计学意义（P〈0.05）。但两组治疗后细菌培养转阴率差异无统计学意义（P〉0.05）。结论：联合应用热淋清颗粒及化学药治疗慢性前列腺炎可迅速改善症状,疗效显著。

Efficacy of Relinqing Granules Combined with Western Medicine for Chronic Prostatitis

OBJECTIVE：To study the clinical efficacy of Relinqing granules combined with western medicines in the treatment of chronic prostatitis. METHODS： By a randomized and controlled clinical trial,a total of 137 patients with chronic prostatitis were enrolled （in whom 24 were with bacterial chronic prostatitis and 113 nonbacterial） were randomized to either control group （n=52） receiving western medicines （sensitive antibiotics,α1-receptor inhibitor and physiotherapy such as sitz bath with warm water） or trial group （n=85） receiving western medicines similar to the control group plus Relinqing granules （4 g,t.i.d）. The curative efficacy was evaluated in accordance with the criteria of the National Institute of the Health Chronic Prostatitis Symptom Index （NIH-CPSI） and PPMT as well as the results of bacteriologic test. RESULTS： All patients were followed up for an average of 8.3 months. NIH-CPSI,PPMT and the bacteriologic test results were compared before and after treatment. The trial group achieved a curative rate of 14.1% （12/85）,a remarkable effective rate of 55.3% （47/85）,an effective rate of 20% （17/85） and a non-effective rate of 10.6% （9/85）,with NIH-CPSI score of 27.7（28.5±4.2） before treatment vs. 13.2 （12.9± 3.6） after treatment （P〈0.01）. In control group,the curative rate was 7.7% （4/52）;the remarkable effective rate was 17.3% （9/52）;the effective rate was 46.2% （24/52） and the non-effective rate was 28.8% （15/52）,with NIH-CPSI score being 27.2 （27.8±3.6） before treatment vs. 17.3（17.54±2.7） after treatment （P〉0.05）. Before and after the treatment,the PPMT results showed significant differences in total effective rate （WBC returned to normal） between the trial group and the control group （68.2% vs. 34.6%,P〈0.05）. However,the bacterial culture showed no difference between two groups after treatment （P〉0.05）. CONCLUSION： The combination of Relinqing granules and western medicine may significantly improve the symptoms with remarkable curative efficacy for patients with chronic prostatitis.