药物联合治疗急性脑梗死的疗效及对血液凝血机制的影响

目的：观察奥扎格雷钠联合银杏达莫注射液治疗急性脑梗死的疗效并进一步对血液凝血机制的影响。方法：两家医院近年住院治疗的急性脑梗死患者64例随机分为观察组和对照组各32例,两组均根据病情给予控制血压、脑保护、降糖、调脂等常规治疗,其中观察组同时应用奥扎格雷钠80mg＋0.9%氯化钠注射液250mL,银杏达莫注射液20mL＋0.9%氯化钠注射液250mL,均为每日1次治疗,疗程14d,观察比较两组的疗效及神经功能缺损评分的变化情况,以及对凝血酶原时间（PT）、凝血酶原标准化比值时（INR）、纤维蛋白原（FIB）、活化部分凝血活酶时间（APTT）、凝血酶时间（TT）等血液凝血指标的影响。结果：两种药物联合治疗急性脑梗死的总有效率经治疗后为87.5%,明显高于对照组,神经功能缺损程度评分治疗后明显降低,明显低于对照组,有统计学意义。观察组GCS评分治疗后明显升高,明显高于对照组,有统计学意义。观察组治疗后凝血酶原时间（PT）、凝血酶原标准化比值时（INR）、纤维蛋白原（FIB）、活化部分凝血活酶时间（APTT）、凝血酶时间（TT）等血液流变学指标均明显改善,差别均具有统计学意义（P〈0.05）。结论：两种药物联合治疗急性脑梗死的疗效更显著,且安全性好,可以明显改善微循环,降低血液粘滞度,值得临床推广应用。

Efficacy of Sodium Ozagrel Combined Yinxingdamo for Acute Cerebral Infarction and Its Effect on Hemorheology

OBJECTIVE：To explore the efficacy and safety of sodium ozagrel combined Yinxingdamo for acute cerebral infarction and its impact on hemorheology.METHODS：64 patients with acute cerebral infarction hospitalized in our hospital were randomly divided into two groups of 32 each.Both groups received antihypertensive,hypoglycemic,hypolipidemic agents according to patients＇condition,and the treatment group was assigned to receive concurrent sodium ozagrel 80 mg ＋ 0.9% sodium chloride injection 250 mL q.d and gingko injection 20 mL ＋0.9% sodium chloride injection 250 mL q.d for 14 days.The clinical efficacy and National Institutes of Health Stroke Scale（NIHSS） scores as well as the effects on PT,INR,FIB,APTT,TT etc were recorded.RESULTS：The total effective rate was 87.5% in the treatment group,which was significantly higher than in the control group,and the NIHSS scores were significantly decreased after treatment,which was significantly lower than in the control group,the differences were significant.After treatment,the GCS scores in the treatment group were significantly higher than in the control group,and the difference between the groups was significant;and the treatment group had a better improvement in PT,INR,FIB,APTT and TT than in the control group,and the differences were all statistically significant（P 〈0.05）.CONCLUSION：Sodium ozagrel combined Yinxingdamo is effective and safe in the treatment of acute cerebral infarction in that it can significantly improve microcirculation,increase red blood cell deformability and reduce blood viscosity,hence its application is worthy of being recommended in clinical practice.