The tissue factor–factor VIIa complex: procoagulant activity, regulation, and multitasking |
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| Authors: | D. M. MONROE N. S. KEY |
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| Affiliation: | Center for Thrombosis and Hemostasis, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA. dmonroe@med.unc.edu |
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| Abstract: | Greater understanding of the cellular interactions associated with tissue factor (TF), activated factor (F) VII and TF-FVIIa complexes is likely to provide considerable clinical benefit. This article reviews current knowledge on the function and regulation of TF and its role in a range of biological processes, including hemostasis, thrombosis and inflammation. |
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| Keywords: | activated factor VII coagulation tissue factor |
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