循环EPCs CD34^＋水平与高血压病患者心血管危险因素的关系

目的探讨能否将循环内皮祖细胞(EPCs)CD34 水平作为评价高血压病患者心血管危险度的标志。方法高血压病患者组62例,对照组20例。高血压病患者采用Framingham心血管危险因素积分分层心血管危险因素,分为低危组18例,中危组14例,高危组17例,极高危组13例。作外周血循环EPCs CD34 水平与Framingham心血管危险因素积分的相关性分析。结果各研究组高血压病患者外周循环EPCs CD34 水平随着其心血管危险程度的增加,逐步下降,各组间比较有统计学意义(P<0.05)。EPCs CD34 水平与Framingham心血管危险因素积分呈负相关关系(r=-0.875,P<0.01)。结论高血压病患者循环EPCs CD34 水平下降与心血管危险因素有显著的相关性。循环EPCs CD34 水平可以作为高血压病患者心血管危险度的标志。

Relationship between Circulating EPCs CD34+ Cells and Cardiovascular Risk in Hypertension

Objective To evaluate whether the variations in the number of circulating endothelial progenitor cells(EPCs)CD34 could be presented as the maker of cardiovascular risk in patients (pts) with hypertension.Methods Sixty-two pts with hypertension and 20 healthy controls were collected.Pts stratified by cardiovascular risk factors according to Framingham risk factors score were divided into low-risk group (n=18),mid-risk group (n=14),high-risk group (n=17) and much-high-risk group (n=13).The level of peripheral circulating EPCs CD34 was measured.The relationships between circulating EPCs CD34 and Framingham cardiovascular risk factors was analyzed.Results The level of peripheral circulating EPCs CD34 was significantly lower in pts with hypertension than that in control group (P<0.05),and CD34 cells were inversely correlated with cardiovascular risks.There was a negative correlation between the level of circulating EPCs CD34 and Framingham cardiovascular risk factors(r=-0.875,P<0.01).Conclusion The level of peripheral circulating EPCs CD34 cells was significantly reduced with the increase of score of cardiovascular risk factors.This study demonstrated that the level of circulating EPCs was a predictor of cardiovascular risk in pts with hypertension.