功能性消化不良患者的情绪障碍及治疗

目的：探讨抗抑郁药对功能性消化不良（ＦＤ）患者情绪障碍的疗效。方法：分别对２４例健康人和２４例ＦＤ病人进行汉密尔顿抑郁量表（ＨＡＭＤ）、汉密尔顿焦虑量表（ＨＡＭＡ）和症状自评量表（ＳＣＬ９０）评分；用抗抑郁药，５羟色胺再摄取抑制剂（ＳＳＲＩ）盐酸氟西汀（百忧解）、帕罗西丁（赛尔特）治疗２４例ＦＤ病人，疗程均为８周，治疗后再进行上述量表评分。结果：ＦＤ患者和正常人的三种量表（ＨＡＭＤ、ＨＡＭＡ、ＳＣＬ９０）评分对比，均显示ＦＤ患者的精神和躯体症状与正常人之间存在着显著差异（ｐ＜０００１）；而在日夜变化和精神病理上，差异无显著性；ＦＤ病人接受抗抑郁药治疗８周后，前后评分对比，患者的精神和躯体症状均有明显改善。结论：提示ＦＤ患者普遍存在抑郁和焦虑情绪，用抗抑郁药治疗ＦＤ能显著改善患者的症状，包括精神和躯体两方面的症状

Psychological Factors in Functional Dyspepsia and its Treatment

Objective:to investigate the role of psychological factors in functional dyspepsia(FD) and the effect of antidepressant on FD.Medthod:to analyze the psychological staus of 24 FD patients and 24 healthy persons using Hamilton Depression(HAMD),Hamilton Anxiety(HAMA)and SCL 90 scales.Antidepressants were used to treat FD patients for 8 weeks,13 cases received Prozac,the other 11 Seroxat.Mental state evaluation was done before and after the treatment.Result:there was significant difference in somatic and psychological scores of HAMA and SCL 90 between the two groups(p<0 001).The scores of FD patients significantly improved after 8 weeks treatment.Conclusion:psychological factors play a role in FD.The patients commonly have depression or anxiety.Antidepressants have good efficiency in the treatment of FD both for improving somatic and psychological symptoms.