Left ventricular hypertrophy in hypertensive type 2 diabetic patients according to renal function |
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Authors: | A. Blanchet Deverly P. Kangambega K. Hue J.-P. Donnet H. Merault L. Foucan |
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Affiliation: | 1. Unité d’exploration cardiovasculaire, CHU de Point-à-Pitre Abymes, route de Chauvel, 97159 Pointe-à-Pitre, Guadeloupe;2. Research group Clinical Epidemiology and Medicine, University of Antilles and Guyane, University Hospital Center of Pointe-à-Pitre, 97159 Pointe-à-Pitre, Guadeloupe;3. Diabetic Foot Unit, University Hospital Center of Pointe-à-Pitre, 97159 Pointe-à-Pitre, Guadeloupe;4. Nephrology Unit, University Hospital Center of Pointe-à-Pitre, 97159 Pointe-à-Pitre, Guadeloupe;5. Diabetology Unit, University Hospital Center of Pointe-à-Pitre, 97159 Pointe-à-Pitre, Guadeloupe;6. Medical information and Public Health Department, University Hospital Center of Pointe-à-Pitre, 97159 Pointe-à-Pitre, Guadeloupe |
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Abstract: | AimCardiovascular disease is the main cause of death in diabetic patients undergoing haemodialysis. Dialysis and hypertension increase left ventricular hypertrophy (LVH), a strong predictor of cardiovascular events. This study evaluated left ventricular structure and function in three groups of hypertensive type 2 diabetic patients with different renal function, and assessed the factors associated with LVH, in an Afro-Caribbean population.MethodsLeft ventricular structure and function were measured by ultrasonography. Group 1 consisted of 150 patients with normal renal function, group 2 included 183 patients with renal dysfunction and the third group comprised 75 dialysis patients.ResultsLeft ventricular mass/height2.7 increased from group 1 to groups 2 and 3 (49.00 g/m2.7, 57.12 g/m2.7 and 59.75 g/m2.7, respectively; P < 0.0001). The prevalences of LVH were 48.3% in group 1, 64.8% in group 2 and 70.3% in the dialysis patients (P = 0.001). LVH was more concentric than eccentric in groups 2 and 3.The factors significantly associated with LVH were obesity in groups 1 and 2, and an increase of 10 mmHg in pulse pressure in groups 2 and 3, according to multivariate logistic-regression analysis.ConclusionOur study confirmed that, in a population of Afro-Caribbean hypertensive type 2 diabetic patients, renal failure was associated to an increased left ventricular mass/height2.7. The data show that the variables associated with LVH differ according to renal profile. This finding will be of value in the treatment and follow-up of these patients. |
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Keywords: | Echocardiography Dialysis Type 2 diabetes mellitus Hypertension Pulse pressureMots clé s: É chocardiographie Dialyse Diabè te de type 2 Hypertension Pression pulsé e |
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