子宫动脉栓塞治疗子宫肌瘤对女性激素的影响

目的 探讨子宫动脉栓塞术(UAE)治疗子宫肌瘤对女性分泌功能的影响.方法 31例子宫肌瘤患者行UAE后随访3～6个月,观察月经变化及监测血清卵泡刺激素(FSH)、黄体生成素(LH)、孕酮(Prog)、雌二醇(E2)4种性激素变化.同时于介入手术前及术后3、6个月分别行B超检查测定肌瘤体积及肌瘤的供血状况.结果 25例(80.6%)UAE后恢复正常月经,临床症状明显改善,4例(12.9%)有一过性月经紊乱(3～6个月恢复正常),2例(0.06%)出现闭经(年龄45岁、49岁).31例患者4种血清性激素术前、术后变化差异无统计学意义(P＞0.05).结论 UAE是一种有效的治疗手段,对女性血清性激素无明显影响,但年龄大于45岁以上者可能出现闭经.

Uterine artery embolizaton for uterine leiomyomas:impact on serum level of sex hormones

Objective To investigate the impact of uterine artery embolization(UAE)for leiomyomas of uterus on serum level of sex hormones.Methods UAE were performed on 31 patients with leiomyomas of uterus.Changes of menses were followed up within 3-6 months after UAE.Serum levels of sex hormones,including FSH,LH,Prog,E2 were tested before and 3 months or 6 months after UAE;and simultaneously with recording the tumor size and the changes of blood dynamics by color Doppler.Results Twenty-five patients(80.6%)with menorrhagia resumed normal after UAE,and a transient menstrual disorder occurred in 4 patients(12.9%).Only 2 patients(0.06%)aged 45 years and 49 years became menopausal following the procedure.Serum levels of sex hormones showed no significant difference before and 3 months or 6 months after UAE(P > 0.05)in 31 patients.Conclusion UAE is an effective treatment for uterine leiomyomas and possesses no influence on serum levels of sex hormones.However,for patients aged 45 or older,there is possibility of menopause.