| 艾迪注射液及联合应用化疗药物抑制人卵巢癌细胞株A2780增殖的研究 |
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| 引用本文： | 刘德艳,李辅军,王常玉,黄磊,李芳,张萍,卢运萍,马丁. 艾迪注射液及联合应用化疗药物抑制人卵巢癌细胞株A2780增殖的研究[J]. 现代妇产科进展, 2005, 14(1): 47-49 |
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| 作者姓名： | 刘德艳 李辅军 王常玉 黄磊 李芳 张萍 卢运萍 马丁 |
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| 作者单位： | 1. 湖北省潜江市江汉石油管理局中心医院妇产科
2. 华中科技大学同济医学院附属同济医院妇产科,武汉,430030 |
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| 基金项目： | 国家杰出青年科研基金资助项目 (30 0 2 5 0 17)，国家重点基础研究发展规划资助项目 (2 0 0 2CB5 1310 0 ) |
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| 摘 要： | 目的 :探讨艾迪注射液对人卵巢癌细胞株A2 780增殖的影响及与多种化疗药物的协同作用。方法 :采用MTT法测定艾迪注射液与 4种化疗药物单独及联用对A2 780细胞的增殖抑制作用 ,运用流式细胞仪测定艾迪注射液对A2 780细胞周期的影响及凋亡率。结果 :艾迪注射液可抑制A2 780细胞增殖 ,其抑制作用呈剂量和时间依赖性 ,并可诱导细胞凋亡。低浓度的艾迪注射液与化疗药物联用 ,可产生较强的抑制细胞增殖的作用。结论 :艾迪注射液具有直接抗肿瘤作用 ,对化疗药物协同作用的机制可能与其诱导细胞凋亡有关。
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| 关 键 词： | 艾迪注射液 卵巢肿瘤 药物疗法 抗增殖 细胞周期 细胞凋亡 |
| 文章编号： | 1004-7379(2005)01-0047-03 |
| 修稿时间： | 2004-06-15 |
Effect of Aidi injection on the proliferation of ovarian carcinoma cell line A2780 and its synergetic effect with chemotherapy drugs |
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| Liu Deyan,Li Fu jun,Wa ng Changyu,et al.. Effect of Aidi injection on the proliferation of ovarian carcinoma cell line A2780 and its synergetic effect with chemotherapy drugs[J]. Current Advances In Obstetrics and Gynecology, 2005, 14(1): 47-49 |
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| Authors: | Liu Deyan Li Fu jun Wa ng Changyu et al. |
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| Affiliation: | Liu Deyan,Li Fu jun,Wa ng Changyu,et al.Department of Obstetrics and Gynecology,Affiliated Tongji Hosp ital of Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430030 |
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| Abstract: | Objective:To investigate the effect of Aidi injection(Ai di) on the proliferation of human ovarian cancer cell line A2780 and the synerge tic effect of Aidi and several chemotherapy drugs in vitro.Method: The effect of Aidi and four chemotherapy drugs on ovarian carcinoma A2780 c ells was detected by MTT assay and flow cytometry.Results:Aidi was effective in inhibiting the proliferation and inducing the apoptosis of A27 80 cells,which was in a dose- and time-dependent manner.Aidi in low concentrat i on had synergetic effect with several chemotherapy drugs.Conclusions: Aidi has a direct anticancer effect and the synergetic antiproliferative effect with chemotherapy drugs may be relative to its cell apoptosis-inducing. |
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| Keywords: | Aidi injection Ovarian neoplasms Drug therapy Antiproliferation Cell cycle Apoptosis |
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