高原肺水肿患者治疗前后抗氧化能力及内皮功能的改变

目的　观察高原肺水肿患者抗氧化能力及内皮功能的变化 ,探讨其变化对高原肺水肿发生、发展的影响。方法　对 34例高原肺水肿患者进行治疗前、治愈后超氧化物歧化酶 (SOD)、丙二醛 (MDA)、还原型谷胱甘肽 (GSH)、一氧化氮 (NO)、一氧化氮合酶 (NOS)含量测定 ,并与 2 0名高原正常健康人作比较。结果　高原肺水肿患者血清SOD、GSH、NO及NOS含量在治疗前显著低于治愈后和对照组 (P <0 0 1) ,MDA及内皮素 1(ET 1)含量治疗前显著高于治愈后和对照组 (P <0 0 1) ,治愈后与对照组差异无显著性 (P >0 0 5 )。结论　高原肺水肿患者机体处于氧化胁迫状态 ,脂质过氧化损伤及内皮功能失衡是造成高原肺水肿的重要机制之一 ,对高原肺水肿的发生、发展及转归产生一定的影响

Changes of antioxidative capacity and endothelial func tion before and after treatment among patients with high altitude pulmonary e dema

Objective To investigate the changes of antioxidative capacity and endothelial function among patients with high altitude pulmonary edema (HAPE). Methods The serum levels of SOD, MDA, GSH, NO, NOS and ET-1 were measured before and after treatment among 34 cases of patients with HAPE, and 20 local healthy volunteers served as control. Results The serum levels of SOD, GSH, NO and NOS were lower in patient-group before treatment than after treatment and those in control-group significantly(P<0.01), while the concentration of MDA and ET-1 were higher in patient-group before treatment than after treatment and those in the control-group significantly(P<0.01). The serum levels of SOD, MDA, GSH, NO, NOS and ET-1 were not different between patient-group after treatment and the control-group(P>0.05). Conclusion The results indicated that changes of SOD, MDA, GSH, NO, NOS and ET-1 may participate in the course of HAPE.