Morphine treatment increases clonidine binding in brain cell cultures |
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Authors: | Ronald J. Plishka Joseph H. Neale |
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Affiliation: | Department of Biology, Georgetown University, Washington, DC 20057 U.S.A. |
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Abstract: | Exposure of murine brain cells in culture to 75 μM morphine for 6 days produced an increase in the number of [3H]clonidine binding sites without affecting the apparent affinity. Similar treatment increased the binding of this α2-adrenergic receptor agonist to cell cultures prepared from cerebral cortex but not to cultures of brain minus cortex or to neuroblastoma-glioma hybrid cells which possess both opiate and α2-adrenergic receptors. |
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Keywords: | opiate addiction clonidine cell culture |
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