| 人参皂苷对糖尿病大鼠肾组织基质金属蛋白酶2表达的影响 |
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| 引用本文： | 倪海祥,杨雪辉,朱峰,魏佳平,苏建明,黄琦.人参皂苷对糖尿病大鼠肾组织基质金属蛋白酶2表达的影响[J].中国中西医结合肾病杂志,2009,10(3):211-213. |
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| 作者姓名： | 倪海祥 杨雪辉 朱峰 魏佳平 苏建明 黄琦 |
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| 作者单位： | 浙江省中医院内分泌科,杭州,310006 |
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| 基金项目： | 浙江省中医药管理局科研基金，浙江省教育厅科学研究项目 |
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| 摘 要： | 目的：研究人参皂苷对糖尿病大鼠肾组织基质金属蛋白酶2（MMP-2）及Ⅳ型胶原（ColⅣ）表达的影响,从而探讨人参皂苷防治糖尿病肾脏病变的可能机制。方法：糖尿病大鼠用人参皂苷治疗,肾标本用MMP-2、ColⅣ单克隆抗体行免疫组化染色后经图像分析仪分析。结果：糖尿病大鼠肾小球MMP-2表达较正常对照组明显下降（P〈0.05）,而肾间质MMP-2与正常对照组比较,有增高趋势,但无统计学差异（P〉0.05）。用人参皂苷治疗后,可逆转上述改变。ColⅣ的表达在肾小球和肾间质均较正常对照组上升,经人参皂苷治疗后下降。结论：人参皂苷对糖尿病大鼠肾脏病变有部分保护作用,其机制可能部分通过改善肾组织MMP-2的表达有关。
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| 关 键 词： | 糖尿病肾病 人参皂苷 基质金属蛋白酶2 Ⅳ型胶原 |
Effect of Ginsenoside on Expression of Matrix Metalloproteinase 2 in Diabetic Nephropathy Rats |
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| NI Haixiang,YANG Xuehui,ZHU Feng,et al.Effect of Ginsenoside on Expression of Matrix Metalloproteinase 2 in Diabetic Nephropathy Rats[J].Chinese Journal of Integrated Traditional and Western Nephrology,2009,10(3):211-213. |
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| Authors: | NI Haixiang YANG Xuehui ZHU Feng |
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| Abstract: | Objective:To study the effect of Ginsenoside on the expression of matrix metalloproteinase 2(MMP-2) in kidneys of diabetic rates and to analyze the protecting mechanism of Ginsenoside on diabetic nephropathy.Methods:18 SD rats without any treatments were used as the normal control group.36 rats of diabetic nephropathy was induced by streptozotocin in the rats as the diabetic nephropathy group.The 18 diabetic nephropathy rats were treated with Ginsenoside as the Ginsenoside-treated group and 18 with placebo ... |
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| Keywords: | Diabetic nephropathy Ginsenoside Matrix metalloproteinase- 2 Type Ⅳ collagen |
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