不同粒径的碳酸钙在体外模拟胃肠道环境中的除铅效果比较

目的:比较不同粒径的碳酸钙在体外模拟胃肠道环境中的除铅效果。方法:原子吸收光谱仪测定Pb2+浓度。结果:碳酸钙在模拟胃液中Pb2+没有影响,在pH 6.0模拟肠液中具有除铅效果,除铅效果随碳酸钙粒径减小而增强。结论:碳酸钙粒径对除铅效果有影响,将纳米碳酸钙制备成肠溶生物粘附制剂,可以通过阻断铅的肠肝循环,成为新型驱铅药物。

Comparison of the effect of CaCO3 with different particle size on the removing lead in vitro simulated gastrointestinal tract environment

Purpose： to compare the effect of four different particles of CaCO3 on the removing lead in vitro simulated gastrointestinal tract environment. Method： Pb^2＋ concentration in vitro simulated gastrointestinal tract environment were examined by atomic absorption spectrum. Results： All CaCO3 had no effect on removing Pb^2 ＋ effect in simulated stomach conditions and have effect in pH 6.0 simulated upper of small intestine conditions, the efficacy of the removing Pb^2 ＋ was depending on the particles of CaCO3 , the particle size was smaller, the efficacy was better. Conclusion： Our ndings indicate that nano--CaCO3 may be a useful drug in treatment of lead intoxicated with the mechanism by interference with the enterohepatic circulation of lead if it was developed a dosage form with pH--sensitive material and bioadhesive material.