Retrospective analysis of the results of the treatment of children with histiocytosis]

The results of the treatment of 26 patients with histiocytosis hospitalized in the years 1970-1990 were evaluated. The age of the children at the time of diagnosis was from 4 months to 14 years, mean 32 months. In 4 cases the changes were restricted to the skeletal system, in the remaining 22 patients generalized histiocytosis was present with involvement of the skeleton and/or internal organs, and/or bone marrow. In the group with generalized histiocytosis 3 children had respiratory failure, 5 had hepatic failure, and 6 bone marrow failure. Full remission was obtained in 19 cases. Another 4 ones had persistent focal changes in the bones. Three children died of disease progression. Thus the probability of 10-year survival was for the whole group 0.86 +/- 0.13.