| Abstract: | Objective:To gather the fragmented literature on ethnobotany,phytochemistry and in-vitro activities of medicinal plants of Pakistan being used against common infections caused by Staphylococcus aureus(S.aureus).Methods: A large number of published and unpublished research studies related to the ethnomedicinal,phytochemical and anti-S.aureus activity of medicinal flora of Pakistan published from 1990-2018 were reviewed using online bibliographic databases such as PubMed,Web of Science,Science Direct,ResearchGate and libraries.Results: S.aureus can cause many human ailments including endocarditis,staphylococcal scalded skin syndrome,septic arthritis,respiratory problems with an estimated infection rate of 25%-35% across the globe.This review comprised of 86 medicinal plants.Data showed that people mostly used leaves(50%) for the preparation of traditional medicines.Correlation analysis on the reviewed data revealed that methanolic extract concentrations of medicinal plants was highly significantly positive correlated(r=0.8;P0.01) with the S.aureus zone of inhibitions.S.aureus reportedly showed complete resistant to the commonly used antibiotic erythromycin.Isolated compounds like altheahexacosanyl lactone,cinnamaldehyde,niloticane,gobicusin A,asparacosin A,muzanzagenin,isoagatharesinol,friedelin,inophynone and eugenol were active against S.aureus.This study provided in-vitro proof for the flora of Pakistan used against different infections caused by S.aureus.Conclusions: Antibacterial agents from natural sources could be more effective against bacterial pathogens and will be helpful in minimizing the adverse effects of synthetic drugs,and hence provides a base for the pharmaceutical industries. |
