耻骨后前列腺癌根治术联合内分泌治疗T_3N_1期前列腺癌

探讨前列腺癌根治术联合早期内分泌治疗盆淋巴结阳性前列腺癌(T3N1期)的安全性及疗效。方法 25例T3N1前列腺癌患者,采用耻骨后前列癌根治术,术后应用抗雄治疗9个月。术后分析患者的生存时间、盆淋巴结侵袭数目、切缘阳性率、并发症发生率、控尿恢复时间、生化复发及肿瘤进展情况。结果所有患者手术均获成功,25例术后病理均为盆淋巴结阳性,其中双侧阳性2例,单侧阳性23例,2例为淋巴管内癌。术后切缘阳性者10(40%)例。除1例术后出现尿道直肠漏外无其他严重并发症。所有患者术后均获得良好控尿,平均控尿恢复时间3.5月(0天～9个月)。平均随访时间30.5个月(15～57个月),无一例死亡。20例术后无PSA进展复发。术后生化复发者5例。结论前列腺癌根治术联合早期内分泌治疗T3N1期前列腺癌是安全的,并能获得良好术后控瘤效果和长期生存。

Radical prostatectomy combining with adjuvant hormone therapy for treatment of prostate cancer with pelvic lymph node metastasis

Objective To evaluate the safety and efficacy of radical prostatectomy combining with adjuvant hormone therapy for the treatment of prostate cancer with positive pelvic lymph nodes(N+ Pca).Methods Twenty-five patients with N+ Pca underwent retropubic radical prostatectomy and followed by adjuvant hormone therapy for 9 months.The positive lymph node,continence rate,PSA-free survival time and the overall survival rate(OST) were analyzed.Results All surgeries were successfully performed in 25 N+ Pca patients.O...