少突胶质前体细胞与髓鞘形成及再生的研究进展

脱髓鞘病变可阻碍神经系统电传导,导致功能障碍。髓鞘再生由广泛分布于成体的少突胶质前体细胞(OPC)介导。理解少突胶质细胞生理学,了解髓鞘形成与维稳机制,了解在某些主要神经系统病变(如多发性硬化)CNS髓鞘再生失败与内源性OPC数量、迁移以及形成髓鞘能力的关系,对于改善髓鞘修复策略具有重要意义。

Role of oligodendrocyte precursor cells in myelination and remyelination: recent advance

Demyelination disables saltatory conduction and leads to loss of neural functions. Remyelination is mediated by oligodendrocyte precursor cells (OPCs), which are widely distributed throughout the adult CNS. A better understanding of oligodendrocyte biology, myelination, and maintenance of myelin sheaths, and the failure of remyelination in the CNS, which has been associated with the limited availability, migratory capacity and myelinating ability of endogenous OPCs, is necessary to improve remyelination strategies in a chronic inflammatory demyelinating disease such as multiple sclerosis (MS).