帕罗西汀与氯丙咪嗪治疗脑卒中后抑郁对照研究

目的　 比较帕罗西汀与氯丙咪嗪治疗脑卒中后抑郁的疗效及安全性。方法　 将符合Cc md 2 r抑郁标准的 6 0例脑卒中后抑郁患者随机分 2组 ,分别用帕罗西汀与氯丙咪嗪治疗 6周后 ,采用Hamiton抑郁量表 (HAMD)、Hamilton焦虑量表 (HAMA) ,临床总体评定量表 (CGI)评定疗效 ;采用副反应量表 (TESS)评定副反应。结果　 帕罗西汀与氯丙咪嗪治疗脑卒中后抑郁疗效相当(P >0 .0 5 ) ,且帕罗西汀的副反应较氯丙咪嗪少而轻 ,常见副反应有恶心、口干、头晕等。结论　 帕罗西汀可作为治疗脑卒中后抑郁的首选用药。

CONTRAST STUDY ON THE EFFECTS OF PAROXETINE AND CHLORIMIPRAMINE ON DEPRESSION AFTER PATIENTS'''' CEREBRAL APOPLEXY

Objective To compare the curative effects and safety of paroxetine and chlorimipamine on depression after patients' cerebral apoplexy.Methods 60 cases of depression caused by cerebral apoplex were randomly divided into two groups treated with paroxetine and chlorimipramine respectively for 6 weeds.The curative effects were evaluated according to Hamiltom's depression scale and anxiety scale as well as the clinical total evaluation scale.side effects were evaluated according to the side effect scale.Results Parooxetine and chlorimipramine resulted in similar curative effects on depression.Less side effects were caused by paroxetine than chlorimipramine.The common side effects were nausea,dry mouth and dizziness.Conclusion Paroxetine can be first chosen to treat depression caused by cerebral apoplexy.