| Effects of norepinephrine and isopentenyladenosine on Na~ /Ca~(2 ) exchangecurrents in isolated guinea pig ventricular myocytes |
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| 引用本文： | 顿文,吴博威,赵荣瑞. Effects of norepinephrine and isopentenyladenosine on Na~ /Ca~(2 ) exchangecurrents in isolated guinea pig ventricular myocytes[J]. Acta pharmacologica Sinica, 1998, 0(2) |
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| 作者姓名： | 顿文 吴博威 赵荣瑞 |
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| 作者单位： | 山西医科大学生理教研室 |
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| 摘 要： | 目的：研究去甲肾上腺素（ＮＥ）和异丙肾上腺素（Ｉｓｏ）对Ｎａ＋／Ｃａ２＋交换电流的影响及受体调控机制．方法：应用全细胞电压钳技术的斜坡脉冲程序，测定离体豚鼠心肌细胞准稳态电流电压关系曲线．结果：ＮＥ０００５，００５和５μｍｏｌ·Ｌ－１分别使膜电位＋５０ｍＶ时的Ｎｉ２＋敏感电流增加２９％±９％，７２％±１１％和１２０％±３１％；Ｉｓｏ１５，１５０和１５００ｎｍｏｌ·Ｌ－１分别使该电流增加２８％±２８％，５６％±１３％和１０２％±１２％．ＮＥ和Ｉｓｏ的这种增强效应能被普萘洛尔１０μｍｏｌ·Ｌ－１完全阻断，而酚妥拉明５０μｍｏｌ·Ｌ－１无此作用．结论：ＮＥ和Ｉｓｏ通过兴奋心脏β肾上腺素受体使Ｎａ＋／Ｃａ２＋交换电流增加．
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| 关 键 词： | Na~＋／Ca~(2＋)交换；去甲肾上腺素；异丙肾上腺素；普萘洛尔；酚妥拉明；膜片箝技术；心肌；离子交换 |
Effects of norepinephrine and isopentenyladenosine on Na~ /Ca~2 exchange currents in isolated guinea pig ventricular myocytes |
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| DUN Wen,WU Bo Wei,ZHAO Rong Rui. Effects of norepinephrine and isopentenyladenosine on Na~ /Ca~2 exchange currents in isolated guinea pig ventricular myocytes[J]. Acta pharmacologica Sinica, 1998, 0(2) |
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| Authors: | DUN Wen WU Bo Wei ZHAO Rong Rui |
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| Affiliation: | DUN Wen,WU Bo Wei,ZHAO Rong Rui 1 |
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