| 大黄素对酒精和高脂饲养诱导的大鼠脂肪肝的影响 |
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| 引用本文： | 董慧,陆付耳,高志强,徐丽君,王开富,邹欣. 大黄素对酒精和高脂饲养诱导的大鼠脂肪肝的影响[J]. 中国医院药学杂志, 2005, 25(3): 202-204 |
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| 作者姓名： | 董慧 陆付耳 高志强 徐丽君 王开富 邹欣 |
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| 作者单位： | 华中科技大学同济医学院附属同济医院中西医结合研究所,湖北,武汉,430030 |
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| 摘 要： | 目的:观察大黄素对酒精和高脂饲养诱导的大鼠脂肪肝的防治作用.方法:采用高浓度酒精灌胃合并高脂饮食饲养制备大鼠脂肪肝模型,同时给予大黄素治疗.通过检测血清肝酶活性、肝组织匀浆脂质含量(TG)和肝脏组织学变化,观察不同剂量大黄素对脂肪肝的防治作用,并与正常组和二甲双胍组作对照.结果:模型组大鼠肝脏出现明显的脂肪变性,肝酶活性、血脂和肝组织TG含量明显升高;大黄素治疗组肝细胞脂肪变性显著减轻,肝碱性磷酸酶和g-谷氨酰基转移酶活性、血脂和肝组织TG含量较模型组显著下降,二甲双胍组较模型组差异无显著性.结论:大黄素对脂肪肝有一定的防治作用.
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| 关 键 词： | 脂肪肝 大黄素 酒精 |
| 文章编号： | 1001-5213(2005)03-0202-03 |
| 修稿时间： | 2004-02-02 |
Effects of emodin on murine fatty liver induced by feeding with alcohol and high fat laboratory chow |
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| DONG Hui,LU Fu-er,GAO Zhi-Qiang,XU Li-jun,WANG Kai-fu,ZOU Xin. Effects of emodin on murine fatty liver induced by feeding with alcohol and high fat laboratory chow[J]. Chinese Journal of Hospital Pharmacy, 2005, 25(3): 202-204 |
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| Authors: | DONG Hui LU Fu-er GAO Zhi-Qiang XU Li-jun WANG Kai-fu ZOU Xin |
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| Abstract: | OBJECTIVE To explore the effects of emodin on prevention and treatment of fatty liver in rats.METHODS Animal models with fatty liver were established by feeding high caloric diet and alcohol for 8 weeks. The murine hepatic enzymes activities, blood lipid, liver triglyceride and pathological histology were determined after therapy with emodin and metformin.RESULTS The animal model of alcoholic liver disease was successfully made. Hepatic enzymes activities including alkaline phosphatase and gamma glutamyl transferase, blood and liver triglycerides in emodin treated groups were significantly lower than those of model group.The pathological degree of hepatic steatosis in treated groups was significantly improved.CONCLUSION It is suggested that emodin might be effective in the prevention and treatment of experimental fatty liver disease. |
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| Keywords: | fatty liver emodin alcohol |
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