| 次级淋巴组织趋化因子在胃癌淋巴结转移中的作用 |
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| 引用本文： | 贾忠,封光华,王春友,陈道达. 次级淋巴组织趋化因子在胃癌淋巴结转移中的作用[J]. 外科理论与实践, 2003, 8(1): 47-49 |
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| 作者姓名： | 贾忠 封光华 王春友 陈道达 |
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| 作者单位： | 1. 杭州市第一人民医院普外科,310006
2. 武汉市协和医院普外科,430022 |
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| 摘 要： | 目的：研究次级淋巴组织趋化因子（secondary lymphoid tissue chemokine,SLC)在胃癌淋巴结中的表达，以进一步阐明胃癌淋巴转移的机制。方法：用逆转录聚合酶链反应（RT－PCR）测定29例胃癌组织淋巴结中SLC mRNA的表达。结果：胃癌转移淋巴结中SLC mRNA的表达均显著低于相应的正常胃黏模组织，但其表达与病人的临床病理特征并不相关。结论：在胃癌转移淋巴结中，SLC的表达明显受抑，后者可能在胃癌的淋巴结转移中起了重要作用，提高淋巴结中SLC的表达可能成为控制胃癌转移和复发的又一关键途径。
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| 关 键 词： | 次级淋巴组织趋化因子 胃癌 淋巴结转移 肿瘤转移 |
| 文章编号： | 1007-9610(2003)01-0047-03 |
| 修稿时间： | 2002-09-26 |
Effects of the Expression of SLC mRNA in Gastric Metastatic Lymph Nodes |
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| JIA Zhong ,FENG Guanghua ,Wang Chunyou ,et al.. Effects of the Expression of SLC mRNA in Gastric Metastatic Lymph Nodes[J]. Journal of Surgery Concepts & Practice, 2003, 8(1): 47-49 |
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| Authors: | JIA Zhong FENG Guanghua Wang Chunyou et al. |
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| Affiliation: | JIA Zhong 1,FENG Guanghua 1,Wang Chunyou 2,et al.Department of General Surgery,The First People's Hospital of Hangzhou,Zhejiang |
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| Abstract: | Objective:To investigate the mRNA expression of the secondary lymphoid tissue chemokine(SLC)in human gastric metastatic lymph nodes,in order to elucidate further the mechanism of lymph node metastasis.Methods:The study was designed to investigate semiquantitatively the expression of SLC mRNA in gastric metastatic lymph nodes by the method of RTPCR.Results:The expression of SLC mRNA was significantly reduced in gastric metastatic lymph nodes as compared to that in adjacent non-cancerous tissues.No correlation was observed between the SLC mRNA expression and the clinicopathological characteristics of the gastric cancer.Conclusions:SLC mRNA expression level is suppressed in gastric matastatic lymph nodes.SLC may play an important role in the carcinogenesis of gastric metastatic lymph nodes.Enhancing the expression of SLC mRNA of gastric lymph nodes might become a key approach to control of metastasis and recurrence of gastric cancer. |
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| Keywords: | Gastric tumour Secondary lymphoid tissue chemokine Lymph node metastasis |
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