| 高渗盐液经骨髓腔通路复苏失血性休克犬后EPO、IL-6的变化 |
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| 引用本文： | 谢菲,冷建军,周飞虎,宋青,江朝光.高渗盐液经骨髓腔通路复苏失血性休克犬后EPO、IL-6的变化[J].山东医药,2010,50(16):21-23. |
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| 作者姓名： | 谢菲 冷建军 周飞虎 宋青 江朝光 |
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| 作者单位： | 中国人民解放军总医院,北京,100853 |
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| 基金项目： | 全军医药卫生科研基金 |
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| 摘 要： | 目的探讨经骨髓腔通路输注不同复苏液复苏失血性休克犬后促红细胞生成素（EPO）、白细胞介素6（IL-6）的变化。方法健康杂种犬随机分为3组：7.5%氯化钠羟乙基淀粉40溶液（HSH）组、0.9%生理盐水（NS）组、假手术（Sham）组。建立犬失血性休克模型,分别从胫骨骨髓腔输注HSH、NS两种复苏液,观察复苏后EPO、IL-6的变化。结果复苏后48 h,NS组、HSH组EPO均较Sham组升高（P〈0.05）;复苏后1周HSH组EPO水平仍高于Sham组（P〈0.05）。休克终点,NS组、HSH组IL-6水平均较Sham组升高（P〈0.05）;复苏后2 h HSH组IL-6水平低于NS组（P〈0.05）;复苏后48 h HSH组IL-6水平降至正常。结论HSH经骨髓腔通路复苏失血性休克犬,能够减轻机体的炎症反应,是一种有效的复苏方案。
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| 关 键 词： | 休克 出血性 骨髓 炎症 促红细胞生成素 白细胞介素6 |
Changes of plasma EPO and IL-6 in hemorrhagic shock canine resuscitated with intraosseous hypertonic saline solution |
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| XIE Fei,LENG Jian-jun,ZHOU Fei-hu,SONG Qing,JIANG Chao-guang.Changes of plasma EPO and IL-6 in hemorrhagic shock canine resuscitated with intraosseous hypertonic saline solution[J].Shandong Medical Journal,2010,50(16):21-23. |
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| Authors: | XIE Fei LENG Jian-jun ZHOU Fei-hu SONG Qing JIANG Chao-guang |
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| Institution: | XIE Fei,LENG Jian-jun,ZHOU Fei-hu,SONG Qing,JIANG Chao-guang(The General Hospital of Chinese People\'s Liberation Army,Beijing 100853,P.R.China) |
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| Abstract: | Objective To investigate the changes of plasma erythropoietin(EPO) and interleukin-6(IL-6) in hemorrhagic shock canine resuscitated with intraosseous hypertonic saline.Methods The experiment animals were divided into three groups: HSH group(HSH was perfusd through shin bone cavum medullare ossium),NS group(NS was perfusd through shin bone cavum medullare ossium),Sham group.EPO and IL-6 were detected after resuscitation.Results After 48 hours of resuscitation,EPO in HSH group and NS group were significantly ... |
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| Keywords: | shock hemorrhagic intraosseous inflammation erythropoietin interleukin-6 |
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