| 针药结合对学习记忆障碍大鼠脑乙酰胆碱和乙酰胆碱酯酶的影响 |
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| 引用本文： | 沈梅红,李忠仁,穆艳云,欧阳颀. 针药结合对学习记忆障碍大鼠脑乙酰胆碱和乙酰胆碱酯酶的影响[J]. 南京中医药大学学报, 2002, 18(4): 236-237 |
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| 作者姓名： | 沈梅红 李忠仁 穆艳云 欧阳颀 |
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| 作者单位： | 1. 南京中医药大学第二临床医学院,江苏,南京,210029
2. 中国人民解放军北京军区总医院,北京,100700 |
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| 基金项目： | 江苏省中医药局科研基金 (970 10 ) |
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| 摘 要： | 目的 探讨针药结合对造模大鼠认知功能改善扣枢胆碱能神经递质的机理。方法 腹腔注射东莨菪碱复制大鼠学习记忆障碍模型，观察针药结合对大脑皮层乙酰胆碱酯酶活性及乙酰胆碱含量的影响。结果 针药结合治疗显著拮抗东莨菪碱诱发的胆碱能系统功能减退。结论 针药结合治疗阿尔茨海默病作用优于单纯应用针刺及当归芍药散，这为临床推广应用提供了科学依据。
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| 关 键 词： | 针药结合 乙酰胆碱 乙酰胆碱酯酶 学习记忆障碍 阿尔茨海默病 AD 中医疗法 |
| 文章编号： | 1000-5005(2002)04-0236-02 |
| 修稿时间： | 2002-03-05 |
Effect of Acupuncture Treatment Combined with Pharmacotherapy on Acetylcholine and Acetylcholinesterase in Brain of Rats with Memory Disturbance |
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| SHEN Mei hong ,LI Zhong ren ,MU Yan yun,OUYANG Qi. Effect of Acupuncture Treatment Combined with Pharmacotherapy on Acetylcholine and Acetylcholinesterase in Brain of Rats with Memory Disturbance[J]. Journal of Nanjing University of Traditional Chinese Medicine(Natural Science), 2002, 18(4): 236-237 |
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| Authors: | SHEN Mei hong LI Zhong ren MU Yan yun OUYANG Qi |
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| Affiliation: | SHEN Mei hong 1,LI Zhong ren 1,MU Yan yun1,OUYANG Qi 1 |
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| Abstract: | OBJECTIVE To explore into the mechanism of the effect of acupuncture treatment combined with pharmacotherapy in improving neurotransmitter of rat models.MEHTOD Memory disturbance models were made by injecting scopolamine into the rats' abdominal cavity, so as to observe the effect of acupuncture treatment combined with pharmacotherapy on the activity of acetylcholine and acetylcholinesterase in the cerebral cortex of rats with memory disturbance.RESULT Acupuncture treatment combined with pharmacotherapy could greatly antagonize hypofunction of the cholinergic system induced by scopolamine.CONCLUSION Acupuncture treatment combined with pharmacotherapy has better therapeutic effect than simple acupuncture treatment or treatment with Danggui Shaoyao Powder in treating Alzheimer's disease. This study provides scientific basis for the clinical application of the new method. |
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| Keywords: | acupuncture treatment combined with pharmacotherapy acetylcholine acetylcholinesterase memory disturbance |
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