Visceral anomalies in prenatally adriamycin-exposed rat fetuses: a model for the VATER association |
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Authors: | J Merei S Hasthorpe P Farmer J M Hutson |
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Institution: | (1) The F. Douglas Stephens Surgical Research Laboratory, Royal Children's Hospital, Melbourne, Australia, AU |
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Abstract: | Adriamycin is teratogenic if given to pregnant rats. A wide range of anomalies involving the gastrointestinal, renal, and
cardiovascular systems has been described, similar to the VATER association, yet it is not known if they are identical to
the human pattern. The aim of this study was to document the visceral anomalies in rat fetuses exposed to adriamycin and to
determine their similarities with the congenital defects in humans with the VATER association. The results revealed a spectrum
of very similar anomalies. Furthermore, the characteristics of the tracheo-oesophageal anomalies had a lot of features in
common with the human pattern. We conclude that the adriamycin-treated fetal rat is an excellent model for studying the VATER
association. |
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