| 新疆维、哈两民族载脂蛋白E等位基因多态性与冠心病关联性研究 |
| |
| 引用本文： | 雷玉艳,张晨,汪幸思,曹婷,林爽,王莎莎,艾热提艾山,瓦哈埔·马木,夏梦菊,梁少华,刘荣辉.新疆维、哈两民族载脂蛋白E等位基因多态性与冠心病关联性研究[J].中国免疫学杂志,2012(9):807-809. |
| |
| 作者姓名： | 雷玉艳 张晨 汪幸思 曹婷 林爽 王莎莎 艾热提艾山 瓦哈埔·马木 夏梦菊 梁少华 刘荣辉 |
| |
| 作者单位： | 新疆医科大学第五附属医院;上海华东医院;新疆喀什地区第二人民医院;新疆阿勒泰地区人民医院 |
| |
| 基金项目： | 新疆维吾尔自治区科技支疆项目(No.01091141) |
| |
| 摘 要： | 目的:对比分析新疆维、哈两民族共411人ApoE等位基因多态性与冠心病相关性;同时进行等位基因频率的对比分析。方法:利用酚-氯仿法抽提提取DNA,再将PCR产物进行纯化。SNaPshot多重单碱基延伸反应纯化后得到的延伸产物在ABI3130XL基因分析仪上进行测序。结果:维、哈两民族对照组与冠心病组之间,冠心病与冠心病组之间E2、E3、E4各单倍体,各基因型阳性率居于相同水平P>0.05)。结论:新疆维、哈两民族ApoE等位基因阳性率水平无统计学差异。
|
| 关 键 词： | 新疆维、哈民族 ApoE等位基因多态性 冠心病 血脂 |
The relationship of ApoE gene polymorphism and coronary heart disease between Uighurs and Kazaks in Xinjiang China |
| |
| LEI Yu-Yan,ZHANG Chen,WANG Xing-Si,CAO Ting,LIN Shuang,WANG Sha-Sha,Egeti·Aishan,Wahapu·Mamu,XIA Meng-Ju,LIANG Shao-Hua,LIU Rong-Hui.The relationship of ApoE gene polymorphism and coronary heart disease between Uighurs and Kazaks in Xinjiang China[J].Chinese Journal of Immunology,2012(9):807-809. |
| |
| Authors: | LEI Yu-Yan ZHANG Chen WANG Xing-Si CAO Ting LIN Shuang WANG Sha-Sha Egeti·Aishan Wahapu·Mamu XIA Meng-Ju LIANG Shao-Hua LIU Rong-Hui |
| |
| Institution: | .The Fifth Affiliated Hospital of Xinjiang Medical University,Urumqi 030011,China |
| |
| Abstract: | Objective:To explore the relationship of ApoE gene polymorphism and coronary heart disease and compare the frequency of alleles in nationality of Uygurs and Kazaks.Methods:411 cases were studied.DNA product was extracted by using the Phenol-chloroform method and the PCR outcome was purified.We take advantage of Multiple single base extension reaction to make DNA sequencing on the ABI3130XL analysis meter.Results:The E2,E3,E4 various haploids,various genotypes masculine gender rate resides were in the same level(P>0.05) between the control groups and coronary disease group;and between the coronary disease groups in two nationality of Uygur and Kazak.Conclusion: ApoE allele masculine gender rate level is non-statistics difference in two nationality of Uygur and Kazak in Xinjiang. |
| |
| Keywords: | Xinjiang Uighurs and Kazakh ApoE gene polymorphism Coronary heart disease Blood-lipid |
| 本文献已被 CNKI 等数据库收录！ |
