Protective Effect of Bisoprolol on Beta-1 Adrenoceptor Peptide-Induced Autoimmune Myocardial Damage in Rabbits |
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Authors: | Shinobu Matsui Marie Persson Hua-Mei Fu Mitsuru Hayase Shogo Katsuda Kohei Teraoka Takayuki Kurihara Michael LX FU |
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Institution: | Department of Cardiology, Sahlgrenska University Hospital, G?teborg, Sweden, SE Wallenberg Laboratory, Sahlgrenska University Hospital, G?teborg, Sweden, SE Department of Clinical Pathology, Kanazawa Medical University, Kanazawa, Japan, JP Department of Pathology, Kanazawa Medical University, Kanazawa, Japan, JP Medical Research Institute, Kanazawa Medical University, Kanazawa, Japan, JP
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Abstract: | Idiopathic dilated cardiomyopathy is a severe disease of unknown etiology. Accumulating evidence suggests that agonist-like autoantibodies against the beta 1 adrenoceptor in the circulation of dilated cardiomyopathy may play an important role. The aim of this study was to evaluate the effects of the selective beta 1-adrenoceptor blocker, bisoprolol, on beta 1-adrenoceptor peptide induced autoimmune myocardial damage. In the animal model of autoimmune cardiomyopathy induced by active immunization of rabbits with beta 1-adrenoceptor peptide, bisoprolol was given at a dose of 3 mg/day throughout the study period. Our results showed high titer of anti-beta 1-adrenoceptor antibody in the immunized group throughout the study but not in the group receiving only bisoprolol. Cross-reactivity to beta 2 adrenoceptors was observed in some of the immunized rabbits, but disappeared almost entirely after 6 months. As compared to the beta 1-adrenoceptor peptide immunized group without bisoprolol treatment, bisoprolol treated beta 1-receptor peptide immunized group showed increase in the wall thickness and decreases in cavity dimension in anatomical measurements and only mild alterations in macro- and microscopic examinations. Thus, our study clearly demonstrated a beneficial effect of bisoprolol in rabbits who have developed autoimmune myocardial damage. |
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